Ebastine Impurity 18 CAS CATO-C4X-202918
| CAS No. | CATO-C4X-202918 |
| Molecular Formula | C11H14ClN2O4P |
| Molecular Weight | 304.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ebastine Impurity 18 (C11H14ClN2O4P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Ebastine Impurity 18 (CAS CATO-C4X-202918, C11H14ClN2O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14ClN2O4P |
| Molecular Weight | 304.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ebastine Standards
- Ebastine EP Impurity D (CAS 97928-18-2)
- Ebastine Impurity 16 (CAS CATO-C4X-202916)
- Ebastine Impurity 17 (CAS CATO-C4X-202917)
- Ebastine Impurity 19 (CAS CATO-C4X-202919)
- Ebastine Impurity 24 (CAS CATO-C4X-202924)
- Ebastine Impurity 25 (CAS CATO-C4X-202925)
- Ebastine Impurity 9 (CAS 632-50-8)
- Ebastine EP Impurity C (CAS 58258-01-8)
Recommended Standards
- 1-(Benzyloxy)-3-chloro-2-fluoro-5-(trifluoromethyl)benzene (CAS 2586127-04-8)
- Flufenzine (CAS 162320-67-4)
- 5-(Benzyloxy)-1-chloro-2-fluoro-3-(trifluoromethyl)benzene (CAS 1881291-55-9)
- 5-((2-Chloro-4-nitrophenyl)amino)-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 1090790-03-6)
- N-Nitroso Dequalinium impurity 36 (CAS CATO-C4X-193636)
- Palonosetron Impurity 42 (CAS 2216755-70-1(free base))
- Ulipristal Impurity 26 (CAS 14340-01-3)
- (R)-1-(2-methoxypyridin-3-yl)propan-2-ol (CAS 1432621-22-1)
- Terbium(III) trifluoromethanesulfonate (CAS 148980-31-8)
- 6,6-Dimethyl-3-((3-(trifluoromethyl)phenyl)amino)-5,6,7-trihydro1H-indazol-4-hydrazone (CAS 1159976-62-1)
- Fmoc-D-3,3-diphenylalanine (CAS 189937-46-0)
- (R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-ol (CAS 921592-86-1)
- 2-(5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzoic acid (CAS 56894-46-3)
- endo-Arg30-Semaglutide (CAS CATO-C4X-2226281)
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