Doxorubicin Impurity 33 CAS CATO-C4X-203333
| CAS No. | CATO-C4X-203333 |
| Molecular Formula | C27H29NO11 |
| Molecular Weight | 543.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Doxorubicin Impurity 33 (CAS CATO-C4X-203333, C27H29NO11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Doxorubicin Impurity 33 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 543.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H29NO11 |
| Molecular Weight | 543.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Doxorubicin Standards
- Doxorubicin Impurity 9 (CAS CATO-C4X-20339)
- Doxorubicin (CAS 23214-92-8)
- Doxorubicin Impurity 20 (CAS CATO-C4X-203320)
- Doxorubicin Impurity 29 (CAS CATO-C4X-203329)
- Doxorubicin Impurity 28 (CAS CATO-C4X-203328)
- Doxorubicin Impurity 3 (CAS 69429-21-6)
- Doxorubicin Impurity 34 (CAS CATO-C4X-203334)
- Doxorubicin Impurity 26 (CAS CATO-C4X-203326)
Recommended Standards
- Epirubicin EP Impurity C (CAS CATO-C4X-11163)
- Epirubicin (CAS 56420-45-2)
- Idarubicin Impurity 15 (CAS 97777-78-1)
- N-(2-(2-(((Benzyloxy)carbonyl)amino)-6-oxo-3,6-dihydro-9H-purin-9-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine (CAS 169287-77-8)
- Gemcitabine Impurity 9 (CAS 143157-22-6)
- Canagliflozin Impurity 24 (CAS 2348-31-4)
- Ceftriaxone EP Impurity C (CAS CATO-C4X-116342)
- Ethyl (5-amino-3-((methyl(phenyl)amino)methyl)pyrido[3,4-b]pyrazin-7-yl)carbamate (CAS 83269-13-0)
- N-Benzoyl-DL-phenylalanine 2-Naphthyl Ester (CAS 15873-25-3)
- Trans-1,2-Dichloroethene (CAS 156-60-5)
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)phenyl)-4-fluorobenzenesulfonamide (CAS 338773-45-8)
- Phosphoric acid, C12-15-alkyl esters, compds. with polyethylene glycol mono[2-(dibutylamino)ethyl] ether (CAS 72207-81-9)
- N-Benzyl-2-bromo-N-phenylpropanamide (CAS 93010-41-4)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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