Gemcitabine Impurity 9 CAS 143157-22-6
| CAS No. | 143157-22-6 |
| Molecular Formula | C19H16F2O6 |
| Molecular Weight | 378.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Gemcitabine Impurity 9 (CAS 143157-22-6), a pharmacopoeial impurity reference standard (molecular formula C19H16F2O6, MW 378.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Gemcitabine Impurity 9 (C19H16F2O6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 378.32 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H16F2O6 |
| Molecular Weight | 378.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Gemcitabine Standards
- Gemcitabine Impurity 16 (CAS 1173824-58-2)
- Gemcitabine Impurity 11 (CAS 143157-25-9)
- Gemcitabine Impurity 10 (CAS 1217452-91-9)
- Gemcitabine Impurity 17 (CAS 197452-15-6)
- Gemcitabine Impurity 29 (CAS 122111-02-8)
- Gemcitabine Impurity 32 (CAS 122111-01-7)
- Gemcitabine monophosphate (disodium) (CAS 1638288-31-9)
- Gemcitabine Impurity 31 (CAS 142816-70-4)
Recommended Standards
- Methyl 2-{[di(iSopentyloxy)phosphoryl]oxy}-3,3,3-trifluoropropanoate (CAS 256332-94-2)
- 4-((Diphenylcarbamoyl)oxy)-3-nitrobenzoic acid (CAS 10556-88-4)
- 5-(2,4-Dichlorophenyl)-4-(2,6-diethylphenyl)-4H-1,2,4-triazole-3-thiol (CAS 380431-24-3)
- 3-(2-Bromophenyl)-1-(4-(thiophen-2-yl)piperidin-1-yl)propan-1-one (CAS 1797309-61-5)
- Tetracaine Impurity 21 (CAS CATO-C4X-192321)
- Cefazolin Impurity 67 (CAS CATO-C4X-157767)
- Rasagiline Impurity 75 HCl (CAS 1016719-48-4 (free base))
- 4-Tert-butyl-1,3-thiazole-5-carboxylic acid (CAS 81569-32-6)
- Fmoc-DL-Ala-OL (CAS 851678-69-8)
- (R)-5-(4-(Trifluoromethyl)phenyl)morpholin-3-one (CAS 1344584-09-3)
- 3-[(2-nitrophenyl)amino]propanenitrile (CAS 33141-24-1)
- 3,5-Dimethyl-4-nitrophenol (CAS 5344-97-8)
- Methyl 3,5-difluoro-2-methylphenylacetate (CAS 1803873-94-0)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com