Osimertinib Impurity 81 CAS CATO-C4X-204581
| CAS No. | CATO-C4X-204581 |
| Molecular Formula | C27H30N8O3 |
| Molecular Weight | 514.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Osimertinib Impurity 81 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Osimertinib Impurity 81 (CAS CATO-C4X-204581), a pharmacopoeial impurity reference standard (molecular formula C27H30N8O3, MW 514.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Osimertinib Impurity 81 (C27H30N8O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 514.58 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Osimertinib Impurity 81 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H30N8O3 |
| Molecular Weight | 514.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related Osimertinib Standards
- Osimertinib Impurity 37 (CAS CATO-C4X-204537)
- Osimertinib Impurity 80 (CAS CATO-C4X-204580)
- Osimertinib Impurity 113 (CAS CATO-C4X-2045113)
- Osimertinib Impurity 42 (CAS 3086362-46-8)
- Osimertinib-4 (CAS 1805787-93-2)
- Osimertinib D6 (CAS 1638281-44-3)
- Osimertinib Impurity 60 (CAS CATO-C4X-204560)
- Osimertinib-13CD3 (CAS 2254100-49-5)
Recommended Standards
- (1S,3S)-1-(3-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (CAS 1137264-00-6)
- Raltitrexed Impurity 4 (CAS 132463-02-6)
- Cefpirome Impurity 3 (CAS 130431-30-0)
- trans-Ned-19 (CAS 1354235-96-3)
- Posaconazole Impurity 205 (CAS CATO-C4X-1208205)
- Exemestane Impurity 19 (CAS CATO-C4X-164119)
- Landiolol Impurity 93 (CAS CATO-C4X-262193)
- 4,6-Difluoro-2,3-dihydro-1H-inden-1-amine hydrochloride (CAS 1199782-88-1)
- 2-Butylhexanoic Acid (CAS 3115-28-4)
- 2,4,5-Trifluoro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide (CAS 125290-71-3)
- 2-(2-(4-Butoxybenzyl)-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)acetic acid (CAS 64677-98-1)
- 6-Iodohexan-1-amine hydrochloride (CAS 98275-58-2)
- 2-(Methylsulfonyl)-5-(trifluoromethyl)benzaldehyde (CAS 942474-52-4)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com