Ruxolitinib Impurity 57 CAS CATO-C4X-205857
| CAS No. | CATO-C4X-205857 |
| Molecular Formula | C22H28N6 |
| Molecular Weight | 376.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ruxolitinib Impurity 57 (CAS CATO-C4X-205857, C22H28N6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ruxolitinib Impurity 57 (C22H28N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ruxolitinib Impurity 57 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H28N6 |
| Molecular Weight | 376.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 123 (CAS CATO-C4X-2058123)
- Ruxolitinib Impurity 19 (CAS CATO-C4X-205819)
- Ruxolitinib Impurity 66 (CAS CATO-C4X-205866)
- Ruxolitinib Impurity 74 (CAS CATO-C4X-205874)
- Ruxolitinib Impurity 134 (CAS CATO-C4X-2058134)
- Ruxolitinib Impurity 64 (CAS CATO-C4X-205864)
- Ruxolitinib Impurity 29 (CAS CATO-C4X-205829)
- Ruxolitinib Impurity 30 (CAS CATO-C4X-205830)
Recommended Standards
- N1,N2-Bis(4-methoxyphenyl)-1-methylhydrazine-1,2-bis(carbothioamide) (CAS 455880-00-9)
- Propyl (3-(((tert-butoxycarbonyl)amino)methyl)oxetan-3-yl)-L-methioninate (CAS 1620923-89-8)
- 5-(Isopentylthio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione (CAS 906240-03-7)
- N-Desmethyl-4'-hydroxy Tamoxifen-d3 (E/Z Mixture) (CAS 1795139-22-8)
- Binimetinib Impurity 5 (CAS 2509103-99-3)
- Testosterone Impurity 25 (CAS CATO-C4X-132625)
- Piracetam Impurity 45 (CAS CATO-C4X-123545)
- N-(4-(naphthalen-1-yl)phenyl)naphthalen-1-amine (CAS 936916-07-3)
- (S)-1-(1-Isocyanatoethyl)-3-methoxybenzene (CAS 745784-08-1)
- 2-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (CAS 1428929-59-2)
- Iridin (CAS 491-74-7)
- 2-(6-Bromopyridin-3-yl)piperidine-1-carbaldehyde (CAS 1352527-58-2)
- N-(but-3-en-1-yl)-N-ethyl-4-methylbenzenesulfonamide (CAS 10285-79-7)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com