Ruxolitinib Impurity 66 CAS CATO-C4X-205866
| CAS No. | CATO-C4X-205866 |
| Molecular Formula | C20H23N7O |
| Molecular Weight | 377.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ruxolitinib Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ruxolitinib Impurity 66 (CAS CATO-C4X-205866, C20H23N7O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Ruxolitinib Impurity 66 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 377.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H23N7O |
| Molecular Weight | 377.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 123 (CAS CATO-C4X-2058123)
- Ruxolitinib Impurity 19 (CAS CATO-C4X-205819)
- Ruxolitinib Impurity 57 (CAS CATO-C4X-205857)
- Ruxolitinib Impurity 74 (CAS CATO-C4X-205874)
- Ruxolitinib Impurity 134 (CAS CATO-C4X-2058134)
- Ruxolitinib Impurity 64 (CAS CATO-C4X-205864)
- Ruxolitinib Impurity 29 (CAS CATO-C4X-205829)
- Ruxolitinib Impurity 30 (CAS CATO-C4X-205830)
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