Clofazimine Impurity 21 CAS CATO-C4X-207121
| CAS No. | CATO-C4X-207121 |
| Molecular Formula | C27H22ClN5O |
| Molecular Weight | 467.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Clofazimine Impurity 21 (C27H22ClN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Clofazimine Impurity 21 (CAS CATO-C4X-207121, C27H22ClN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H22ClN5O |
| Molecular Weight | 467.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Clofazimine Standards
- Clofazimine (CAS 2030-63-9)
- Clofazimine Impurity 20 (CAS CATO-C4X-207120)
- Clofazimine Impurity N2 (CAS 24396-82-5)
- Clofazimine Impurity 23 (CAS CATO-C4X-207123)
- Clofazimine Impurity 3 (CAS 103051-26-9)
- Clofazimine Impurity 6 (CAS 24028-59-9)
- Clofazimine Impurity 5 (CAS 78182-92-0)
- Clofazimine Impurity 2 (CAS 2158184-11-1)
Recommended Standards
- Edoxaban Impurity 92 (CAS CATO-C4X-106392)
- Bepafant (CAS 114776-28-2)
- Edoxaban Impurity 91 (CAS 1255529-38-4)
- 2-((4-(4-Chlorophenyl)-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(1-cyano-1-cyclopropylethyl)acetamide (CAS 851890-45-4)
- Selegiline EP Impurity D HCl (CAS 115586-38-4)
- Hydrochlorothiazide Impurity 23 (CAS 19477-32-8)
- Nicardipine Impurity 59 (CAS CATO-C4X-171059)
- (2-METHOXYPHENYL)(4-METHYLPIPERAZIN-1-YL)METHANONE (CAS 60811-85-0)
- 3-Methyl-L-phenylalanine (CAS 114926-37-3)
- Tiopronin Dimer Disodium Salt (Mixture of Diastereoisomers) (CAS CATO-C4X-15163)
- Bisoprolol Impurity 84 (CAS CATO-C4X-124784)
- 5,5-Dimethyl-2-(4-(trifluoromethyl)phenyl)-1,3,2-dioxaborinane (CAS 501374-30-7)
- N-[2-(5-Formyl-2-furyl)phenyl]acetamide (CAS 893740-79-9)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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