Hydrochlorothiazide Impurity 23 CAS 19477-32-8
| CAS No. | 19477-32-8 |
| Molecular Formula | C7H7ClN2O2S |
| Molecular Weight | 218.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Hydrochlorothiazide Impurity 23 (CAS 19477-32-8), a pharmacopoeial impurity reference standard (molecular formula C7H7ClN2O2S, MW 218.66 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Hydrochlorothiazide Impurity 23 (C7H7ClN2O2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O2S |
| Molecular Weight | 218.66 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 35 (CAS CATO-C4X-117735)
- Hydrochlorothiazide Impurity 36 (CAS CATO-C4X-117736)
- Hydrochlorothiazide Impurity 54 (CAS CATO-C4X-117754)
- Hydrochlorothiazide Impurity 57 (CAS CATO-C4X-117757)
- Hydrochlorothiazide Impurity 1 (CAS 133-74-4)
- Hydrochlorothiazide Impurity 40 (CAS CATO-C4X-117740)
- Hydrochlorothiazide Impurity 41 (CAS CATO-C4X-117741)
- Hydrochlorothiazide Impurity N17 (CAS 1954-94-5)
Recommended Standards
- 40913-92-6 4-methanesulfonylbenzoyl chloride DTXSID20460905 (CAS 40913-92-6)
- Clofibric-d4 Acid (4-chlorophenyl-d4) (CAS 1184991-14-7)
- Methyl 6-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylate (CAS 6311-74-6)
- 2-(3-Chloropropyl)-5-(difluoromethyl)toluene (CAS 1806371-24-3)
- Loratadine Impurity 88 (CAS CATO-C4X-142688)
- Vericiguat Impurity 82 (CAS CATO-C4X-289682)
- Cefotaxime Impurity 16 (CAS CATO-C4X-120116)
- 2-Ethyl-1-(3-methylphenyl)cyclopropan-1-amine (CAS 1518630-90-4)
- Desmopressin Impurity 42 (CAS CATO-C4X-221542)
- 7-Chloroacridin-2-amine (CAS 23045-20-7)
- 1-(4-Fluorophenyl)cyclohexanecarboxylic Acid (CAS 214263-00-0)
- 1346602-61-6 N~1~,N~4~-Bis{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethyl}-N~1~,N~4~-diphenylbutanediamide DTXSID20858409 (CAS 1346602-61-6)
- N-(2,4-Dimethoxybenzyl)-6-fluoropyridin-2-amine (CAS 1275088-21-5)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com