Lusutrombopag Impurity 37 CAS CATO-C4X-208437
| CAS No. | CATO-C4X-208437 |
| Molecular Formula | C29H33ClN2O6S |
| Molecular Weight | 573.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lusutrombopag Impurity 37 (CAS CATO-C4X-208437, C29H33ClN2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lusutrombopag Impurity 37 (C29H33ClN2O6S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H33ClN2O6S |
| Molecular Weight | 573.10 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lusutrombopag Standards
- Lusutrombopag Impurity 53 (CAS CATO-C4X-208453)
- Lusutrombopag Impurity 69 (CAS CATO-C4X-208469)
- Lusutrombopag Impurity 77 (CAS CATO-C4X-208477)
- Lusutrombopag Impurity 71 (CAS CATO-C4X-208471)
- Lusutrombopag Impurity 61 (CAS CATO-C4X-208461)
- Lusutrombopag (CAS 1110766-97-6)
- Lusutrombopag Impurity 13 (CAS CATO-C4X-208413)
- Lusutrombopag Z-isomer (CAS CATO-C4X-208414)
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