N-nitroso Cyclen Impurity 130(Gadobutrol Impurity 130) CAS CATO-C4X-2120130
| CAS No. | CATO-C4X-2120130 |
| Molecular Formula | C8H16N8O4 |
| Molecular Weight | 288.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-nitroso Cyclen Impurity 130(Gadobutrol Impurity 130).
As a process- or degradation-related impurity, N-nitroso Cyclen Impurity 130(Gadobutrol Impurity 130) (CAS CATO-C4X-2120130, C8H16N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
N-nitroso Cyclen Impurity 130(Gadobutrol Impurity 130) (C8H16N8O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H16N8O4 |
| Molecular Weight | 288.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related N Standards
- N-nitroso norbelladine (CAS CATO-C3D-26169)
- N-Nitroso Nortilidine (CAS CATO-C4X-30951)
- N-Nitroso N-Desmethyl Orphenadrine-d3 (CAS 3028194-83-1 (Non-Labelled))
- N-Nitroso Vilazodone Impurity 14 (CAS CATO-C4X-135514)
- N-Nitroso Ropinirole (CAS CATO-C4X-174518)
- N-Nitroso 1-( 4-Methoxy Benzyl) 1,2,3,4,5,6,7,8-octahydro Isoquinoline (CAS 1801431-26-4)
- N-Nitroso Dextromethorphan EP Impurity A (CAS CATO-C4X-115739)
- 5-Nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedioneDISCONTINUED, offer N546615 (CAS 75599-13-2)
Recommended Standards
- Nicardipine Impurity 41 (CAS CATO-C4X-171041)
- 4-(2-(4-(trifluoromethyl)piperidin-1-yl)acetyl)-1H-pyrrole-2-carbaldehyde (CAS 1000339-90-1)
- Nicardipine Impurity 40 (CAS CATO-C4X-171040)
- {1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}acetic acid (CAS 1018164-10-7)
- Vinorelbine Impurity 24 (CAS CATO-C4X-264224)
- Urapidil Impurity 59 (CAS CATO-C4X-192459)
- Valsartan Impurity 37 (CAS CATO-C4X-105737)
- 7,7-Dimethyl-1-azaspiro[3.5]nonane (CAS 1497917-00-6)
- 5-(4-Piperidinyl)-1H-pyrazol-3-amine dihydrochloride (CAS 1799293-20-1)
- (e)-3-(2,6-Dichlorophenyl)prop-2-en-1-ol (CAS 501922-08-3)
- 4-(((Tert-butoxycarbonyl)amino)methyl)bicyclo[2.2.1]Heptane-1-carboxylic acid (CAS 1956325-65-7)
- Triamcinolone EP Impurity C (CAS 337-02-0)
- Evocalcet Impurity 26 (CAS CATO-C4X-248526)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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