Fluralaner Impurity 53 CAS CATO-C4X-218053
| CAS No. | CATO-C4X-218053 |
| Molecular Formula | C19H13Cl2F3N2O3 |
| Molecular Weight | 445.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Fluralaner Impurity 53 (CAS CATO-C4X-218053, C19H13Cl2F3N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Fluralaner Impurity 53 (C19H13Cl2F3N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H13Cl2F3N2O3 |
| Molecular Weight | 445.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Fluralaner Standards
- Fluralaner Impurity N3 (CAS 864725-61-1)
- Fluralaner Impurity 50 (CAS 1309959-46-3)
- Fluralaner Impurity 23 (CAS CATO-C4X-218023)
- Fluralaner impurity 35 (CAS CATO-C4X-218035)
- Fluralaner impurity 36 (CAS CATO-C4X-218036)
- Fluralaner impurity 32 (CAS CATO-C4X-218032)
- Fluralaner impurity 41 (CAS CATO-C4X-218041)
- Fluralaner impurity 43 (CAS CATO-C4X-218043)
Recommended Standards
- 1-(2,4-Dichloro-5-methoxyphenyl)-5-methyl-N-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazole-3-carboxamide (CAS 339015-15-5)
- 6-(Tributylstannyl)-2,2'-bipyridine (CAS 163630-09-9)
- (5-(4-Chlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl 4-chlorobenzoate (CAS 955964-18-8)
- 2-Amino-7-bromo-4-[2-(trifluoromethyl)phenyl]-4H-benzo[g]chromene-3-carbonitrile (CAS 861208-31-3)
- Sitafloxacin Impurity 31 (CAS CATO-C4X-115531)
- Pemafibrate Impurity 26 (CAS 848258-31-1)
- Cefdinir Impurity 94 (CAS CATO-C4X-121094)
- 3-Methyl-1-isopropyl-1H-pyrazole-4-sulfonyl chloride (CAS 1006453-71-9)
- 4-Bromo-1-isopropyl-1H-pyrrolo-[2,3-b]pyridine-3-carbaldehyde (CAS 1350760-46-1)
- 4-(Methoxymethyl)-3-nitrobenzoic acid (CAS 869186-74-3)
- Chitinase-IN-2 (CAS 1579991-63-1)
- 5-Amino-1-(3,4-dichlorobenzyl)-1H-indazol-3-ol (CAS 197584-46-6)
- 3-Ethyl-3-methylpiperazin-2-one (CAS 890926-67-7)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
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