Roxadustat Impurity 140 CAS CATO-C4X-2213140
| CAS No. | CATO-C4X-2213140 |
| Molecular Formula | C21H15BrN2O5 |
| Molecular Weight | 455.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roxadustat Impurity 140 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Roxadustat Impurity 140 (CAS CATO-C4X-2213140), a pharmacopoeial impurity reference standard (molecular formula C21H15BrN2O5, MW 455.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Roxadustat Impurity 140 (C21H15BrN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H15BrN2O5 |
| Molecular Weight | 455.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Impurity 47 (CAS CATO-C4X-221347)
- Roxadustat Impurity 83 (CAS CATO-C4X-221383)
- Roxadustat Impurity 69 (CAS 2731734-05-5)
- Roxadustat Impurity 52 (CAS CATO-C4X-221352)
- Roxadustat Impurity 117 (CAS CATO-C4X-2213117)
- Roxadustat impurity 110 (CAS CATO-C4X-2213110)
- Roxadustat Impurity 104 (CAS CATO-C4X-2213104)
- Roxadustat Impurity 45 (CAS CATO-C4X-221345)
Recommended Standards
- N-(3-chloro-4-methylphenyl)-2-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)acetamide (CAS 866017-70-1)
- N-((4-fluorobenzoyl)oxy)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 320418-84-6)
- Resmetirom Impurity 51 (CAS CATO-C4X-291251)
- N-(2-Bromo-4,6-difluorophenyl)-2-((4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 578699-95-3)
- Ipragliflozin Impurity 4 (CAS CATO-C4X-18854)
- Safinamide Impurity 47 (CAS 1000370-28-4)
- Gadobutrol Impurity 54 (CAS CATO-C4X-2120154)
- 2-(Allyloxy)-1-naphthaldehyde O-(2,6-dichlorobenzyl) oxime (CAS 866134-96-5)
- 2-Methyl-1-(quinolin-2-yl)propan-2-ol (CAS 29526-24-7)
- tert-Butyl 2-(4-methylpyridin-3-yl)piperidine-1-carboxylate (CAS 1352533-58-4)
- 1-Methyl-1h,2h,3h-pyrazolo[3,4-b]pyridin-3-one (CAS 2942-45-2)
- 2-amino-2-(2-fluorophenyl)acetonitrile hydrochloride (CAS 1251923-68-8)
- (3aR,5E,7S,10E,14E,16aS)-2,7-Dihydroxy-3-((S)-1-hydroxypropan-2-yl)-6,10,14,16a-tetramethyl-3a,4,8,9,12,13,16,16a-octahydrocyclopenta[15]annulen-1(7H)-one (CAS 146436-22-8)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
Why CATO?
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