Phloroglucinol Impurity 66 CAS CATO-C4X-221766
| CAS No. | CATO-C4X-221766 |
| Molecular Formula | C12H8O6 |
| Molecular Weight | 248.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Phloroglucinol Impurity 66 (CAS CATO-C4X-221766, C12H8O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Phloroglucinol Impurity 66 (C12H8O6) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8O6 |
| Molecular Weight | 248.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Phloroglucinol Standards
- Phloroglucinol impurity 54 (CAS CATO-C4X-221754)
- Phloroglucinol impurity 55 (CAS CATO-C4X-221755)
- Phloroglucinol Impurity 65 (CAS CATO-C4X-221765)
- Phloroglucinol Impurity 67 (CAS CATO-C4X-221767)
- Phloroglucinol Related Compound 8 (CAS 121449-71-6)
- Phloroglucinol impurity 64 (CAS CATO-C4X-221764)
- Phloroglucinol Impurity 70 (CAS 61237-21-6)
- Phloroglucinol Impurity 20 (CAS 626-41-5)
Recommended Standards
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- 2-NP-AHD (CAS 623145-57-3)
- Nicergoline EP Impurity B (CAS 35264-46-1)
- Linezolid Impurity 20 (CAS CATO-C4X-107320)
- FCN437 Impurity 2 (CAS CATO-C4X-33242)
- 2-(((2,5-Dimethylphenyl)amino)methyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (CAS 328272-83-9)
- (R)-2-Amino-2-cyclohexylethanol (CAS 85711-13-3)
- 2-(4-Bromophenyl)-acetamidine (CAS 59104-21-1)
- N-(2-methyl-5-nitrophenyl)-N-(methylsulfonyl)glycine (CAS 717854-37-0)
- 1-Methylpiperidine-4-carbothioamide (CAS 88654-17-5)
- 5-(Trifluoromethyl)uridine (CAS 21618-67-7)
- 110207-62-0 Acetyl-Cholecystokinin Octapeptide (2-8) (sulfated) MFCD00133565 (CAS 110207-62-0)
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