Nicergoline EP Impurity B CAS 35264-46-1
| CAS No. | 35264-46-1 |
| Molecular Formula | C23H24BrN3O3 |
| Molecular Weight | 470.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicergoline EP Impurity B.
As a process- or degradation-related impurity, Nicergoline EP Impurity B (CAS 35264-46-1, C23H24BrN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nicergoline EP Impurity B (C23H24BrN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicergoline EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H24BrN3O3 |
| Molecular Weight | 470.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Nicergoline Standards
- Nicergoline Impurity 15 (CAS CATO-C4X-208515)
- Nicergoline EP Impurity E (CAS 57935-66-7)
- Nicergoline EP Impurity H (CAS 192504-81-7)
- Nicergoline (CAS 27848-84-6)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Nicergoline EP Impurity F (CAS 58001-19-7)
- Nicergoline EP Impurity G (CAS 57935-65-6)
- Nicergoline-13C-d3 (CAS CATO-C4X-208513)
Recommended Standards
- Beclometasone Impurity 38 (CAS CATO-C4X-147438)
- N-Boc-3-(2-Bromo-2-ethoxycarbonylvinyl)-2-phenylindole (CAS 1017968-67-0)
- (E)-{[4-(4-chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]methylidene}amino 4-chlorobenzoate (CAS 478041-88-2)
- 3-(3-Hydroxy-1-oxo-1H-inden-2-yl)-4,6-dioxo-5-(3-(trifluoromethyl)phenyl)-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylic acid (CAS 321521-98-6)
- Cefaclor Impurity 68 (CAS CATO-C4X-127068)
- Biapenem impurity 17 (CAS CATO-C4X-227317)
- Avatrombopag Impurity 68 (CAS 2325305-38-0)
- 3-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-5-[(E)-2-(dimethylamino)ethenyl]-1,2-thiazole-4-carbonitrile (CAS 338778-67-9)
- Ipragliflozin Impurity 12 (CAS CATO-C4X-188512)
- 2-Mercapto-4-(4-methoxyphenyl)-6-(trifluoromethyl)nicotinonitrile (CAS 438221-56-8)
- 2-(Ethylthio)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 1263212-88-9)
- (4-(7-(2-(4-Chlorophenoxy)ethyl)-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl)phenyl)phosphonic acid (CAS 1373822-39-9)
- Methyl 2-(4-(4-methylbenzamido)phenoxy)benzoate (CAS 866020-22-6)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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