Polymyxin Impurity 35 TFA CAS CATO-C4X-225535
| CAS No. | CATO-C4X-225535 |
| Molecular Formula | C55H96N16O14S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Polymyxin Impurity 35 TFA (CAS CATO-C4X-225535, C55H96N16O14SC2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Polymyxin Impurity 35 TFA (C55H96N16O14SC2HF3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Polymyxin Impurity 35 TFA meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C55H96N16O14S C2HF3O2 |
| Molecular Weight | 1351.55 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 16 |
| Sulfur Atoms | 1 |
Related Polymyxin Standards
- Polymyxin B - API Standards (CAS 1404-26-8)
- Polymyxin B Sulfate (CAS 1405-20-5)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
- Polymyxin Impurity 56 X Trifluoroacetate (CAS 3034660-94-8 (free base))
- Polymyxin E2 (CAS 30387-41-8)
- Polymyxin Impurity 20 (CAS 343979-23-7)
- Polymyxin B2 (CAS 34503-87-2)
- Polymyxin B2 XTFA Salt (CAS 34503-87-2 (free base))
Recommended Standards
- Edoxaban Impurity 14 (CAS 2244103-96-4)
- Aripiprazole Impurity 89 (CAS CATO-C4X-100889)
- Levofloxacin impurity 77 (CAS CATO-C4X-137177)
- N-Methyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3-amine dihydrobromide (CAS 1474036-15-1)
- 1-(But-2-en-1-yl)-1H-pyrrole-2-carbaldehyde (CAS 169376-25-4)
- (4-(Ethylthio)phenyl)(m-tolyl)methanol (CAS 844683-30-3)
- Methyl 2-(4-methyl-2-oxopyrrolidin-1-yl)acetate (CAS 87148-76-3)
- CAS 35003-18-0 (CAS 35003-18-0)
- 2-Methyl-6-(trifluoromethyl)quinoline (CAS 66023-21-0)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
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