Polymyxin Impurity 42 TFA CAS CATO-C4X-225542
| CAS No. | CATO-C4X-225542 |
| Molecular Formula | C55H96N16O13 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Polymyxin Impurity 42 TFA (CAS CATO-C4X-225542, C55H96N16O13C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Polymyxin Impurity 42 TFA (C55H96N16O13C2HF3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Polymyxin Impurity 42 TFA meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C55H96N16O13 C2HF3O2 |
| Molecular Weight | 1303.49 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 16 |
Related Polymyxin Standards
- Polymyxin B - API Standards (CAS 1404-26-8)
- Polymyxin B Sulfate (CAS 1405-20-5)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
- Polymyxin Impurity 56 X Trifluoroacetate (CAS 3034660-94-8 (free base))
- Polymyxin E2 (CAS 30387-41-8)
- Polymyxin Impurity 20 (CAS 343979-23-7)
- Polymyxin B2 (CAS 34503-87-2)
- Polymyxin B2 XTFA Salt (CAS 34503-87-2 (free base))
Recommended Standards
- Relebactam Impurity 142 (CAS CATO-C4X-2144142)
- Alanyl Glutamine Impurity 18 TFA Salt (CAS CATO-C4X-197418)
- Maxacalcitol Impurity 6 (CAS 514224-59-0)
- 2,5-Dimethyl-1-(2,2,4-trimethyl-2,3-dihydro-1-benzofuran-7-yl)-1H-pyrrole (CAS 866008-60-8)
- 3-amino-5-chloro-4-methylbenzenesulfonic acid (CAS 6387-27-5)
- 2-((6-Bromo-2,8-dimethylquinolin-4-yl)thio)acetonitrile (CAS 1429902-08-8)
- 3-Hydroxy-4-((3-hydroxypropyl)amino)tetrahydrothiophene 1,1-dioxide (CAS 459413-88-8)
- 2-Chloro-5-(1-chloroethyl)-3-methoxy-4-methylpyridine (CAS 2758092-33-8)
- 5-(P-tolyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 676254-55-0)
- Liraglutide-d8 Tetratrifluoroacetate (CAS 204656-20-2 (non-labelled, free base))
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