Carbidopa EP Impurity I CAS CATO-C4X-23109
| CAS No. | CATO-C4X-23109 |
| Molecular Formula | C10H13BrN2O4 |
| Molecular Weight | 305.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Carbidopa EP Impurity I.
CATO supplies Carbidopa EP Impurity I (CAS CATO-C4X-23109), a pharmacopoeial impurity reference standard (molecular formula C10H13BrN2O4, MW 305.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Carbidopa EP Impurity I (C10H13BrN2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13BrN2O4 |
| Molecular Weight | 305.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Carbidopa Standards
- Carbidopa EP Impurity J (CAS 43197-33-7)
- rac-Carbidopa EP Impurity I (CAS 1246819-09-9)
- Carbidopa Impurity 32 (CAS CATO-C4X-231032)
- Carbidopa EP Impurity D (CAS 934371-48-9)
- Carbidopa Hydantoic Acid (CAS 28861-00-9)
- Carbidopa impurity 41 (CAS CATO-C4X-231041)
- Carbidopa Impurity 14 (CAS CATO-C4X-231014)
- Carbidopa Impurity 19 (CAS CATO-C4X-231019)
Recommended Standards
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- N-(4-Bromophenyl)-3-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine (CAS 899953-86-7)
- 2-Chloro-5-(6-oxo-1,6-dihydropyridazin-3-yl)-benzenesulfonyl chloride (CAS 1160264-18-5)
- Clevidipine butyrate Impurity 9 (CAS CATO-C4X-10159)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Fenfluramine Impurity 3 (CAS 713-45-1)
- Thiophen-3-amine oxalate (CAS 861965-63-1)
- Bis(2-isopropyl-5-methylcyclohexyl) ((2-fluorophenyl)(hydroxy)methyl)phosphonate (CAS 382149-58-8)
- 2-Bromo-5-fluoro-4-(trifluoromethyl)benzaldehyde (CAS 2091605-30-8)
- N-[(5-Propyl-1,2,4-oxadiazol-3-yl)methyl]-ethanamine (CAS 915925-27-8)
- (5-((Methylthio)methyl)-1H-1,2,4-triazol-3-yl)methanamine (CAS 1343502-51-1)
- Methyl (E)-4-(3-bromophenyl)-2-oxobut-3-enoate (CAS 1148004-80-1)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
Why CATO?
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