rac-Carbidopa EP Impurity I CAS 1246819-09-9
| CAS No. | 1246819-09-9 |
| Molecular Formula | C10H13BrN2O4 |
| Molecular Weight | 305.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of rac-Carbidopa EP Impurity I (C10H13BrN2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, rac-Carbidopa EP Impurity I (CAS 1246819-09-9, C10H13BrN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13BrN2O4 |
| Molecular Weight | 305.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related rac Standards
- Carbidopa EP Impurity J (CAS 43197-33-7)
- Carbidopa EP Impurity I (CAS CATO-C4X-23109)
- Carbidopa Impurity 32 (CAS CATO-C4X-231032)
- Carbidopa EP Impurity D (CAS 934371-48-9)
- Carbidopa Hydantoic Acid (CAS 28861-00-9)
- Carbidopa impurity 41 (CAS CATO-C4X-231041)
- Carbidopa Impurity 14 (CAS CATO-C4X-231014)
- Carbidopa Impurity 19 (CAS CATO-C4X-231019)
Recommended Standards
- 3-Iodo-6-methyl-8-(methylthio)imidazo[1,2-a]pyrazine (CAS 1094070-47-9)
- 2-Chloro-5-(6-oxo-1,6-dihydropyridazin-3-yl)-benzenesulfonyl chloride (CAS 1160264-18-5)
- Tetradecane-7,8-dione (CAS 6305-47-1)
- 4-(N-Boc-aminomethyl)-2-bromo-3-fluoropyridine (CAS 1350885-66-3)
- Mycophenolic Acid Impurity 13 Disodium Salt (CAS CATO-C4X-212213)
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Venetoclax Impurity 75 (CAS CATO-C4X-249575)
- 1,2-Dibromo-4-ethoxy-3-fluorobenzene (CAS 1804939-30-7)
- 1-(2-Chlorophenyl)-3-(4-(methylthio)phenyl)propan-1-one (CAS 898781-48-1)
- M71-S1Pr (CAS 1212008-99-5)
- 2-(4-Bromobutyl)benzo[d]thiazole (CAS 93322-91-9)
- (3R,4R,5S,6R)-6-(acetoxymethyl)-3-azidotetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 171032-74-9)
- 3-(2-Pyridyldithio)propanoic Acid (CAS 68617-64-1)
- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
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