Upadacitinib Impurity 63 CAS CATO-C4X-240563
| CAS No. | CATO-C4X-240563 |
| Molecular Formula | C16H19Br2NO3 |
| Molecular Weight | 433.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Upadacitinib Impurity 63 (CAS CATO-C4X-240563), a pharmacopoeial impurity reference standard (molecular formula C16H19Br2NO3, MW 433.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Upadacitinib Impurity 63 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 433.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H19Br2NO3 |
| Molecular Weight | 433.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 121 (CAS CATO-C4X-2405121)
- Upadacitinib Impurity 180 (CAS CATO-C4X-2405180)
- Upadacitinib Impurity 127 (CAS CATO-C4X-2405127)
- Upadacitinib Impurity 85 (CAS CATO-C4X-240585)
- Upadacitinib Impurity 132 (CAS CATO-C4X-2405132)
- Upadacitinib Impurity 171 (CAS CATO-C4X-2405171)
- Upadacitinib Impurity 62 (CAS CATO-C4X-240562)
- Upadacitinib Impurity 149 (CAS CATO-C4X-2405149)
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- Ethyl 5-Chloro-7-methyl-1H-indole-2-carboxylate (CAS 15936-71-7)
- Shikimic Acid (CAS 138-59-0)
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- Glycine-13C2,15N (CAS 211057-02-2)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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