Lifitegrast Impurity 101 CAS CATO-C4X-2409101
| CAS No. | CATO-C4X-2409101 |
| Molecular Formula | C29H20Cl4N2O5 |
| Molecular Weight | 618.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 618.29 g/mol gives Lifitegrast Impurity 101 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Lifitegrast Impurity 101 (CAS CATO-C4X-2409101) is a certified pharmaceutical impurity reference standard with the molecular formula C29H20Cl4N2O5 and a molecular weight of 618.29 g/mol.
Structurally, Lifitegrast Impurity 101 (C29H20Cl4N2O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 618.29 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H20Cl4N2O5 |
| Molecular Weight | 618.29 g/mol |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lifitegrast Standards
- Lifitegrast Impurity 85 (CAS CATO-C4X-240985)
- Lifitegrast Impurity 86 (CAS CATO-C4X-240986)
- Lifitegrast Impurity 87 (CAS CATO-C4X-240987)
- Lifitegrast-d4 (CAS CATO-C4X-240951)
- Lifitegrast-d4 (CAS CATO-C4X-240952)
- Lifitegrast Impurity 33 (CAS CATO-C4X-240933)
- Lifitegrast (CAS 1025967-78-5)
- R-Lifitegrast (CAS 2271299-08-0)
Recommended Standards
- 2-(9,9-Bis(6-bromohexyl)-9H-fluoren-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1030020-61-1)
- 4,4′,4′′,4′′′-tetraaza-29<I>H</I>,31<I>H</I>-copper(II) phthalocyanine (CAS 15275-52-2)
- 2,2'-((((2,5-Diiodo-1,4-phenylene)bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(tetrahydro-2H-pyran) (CAS 1956377-70-0)
- Iohexol Impurity 32 (CAS CATO-C4X-166432)
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- Dronedarone Impurity 95 (CAS CATO-C4X-109295)
- Azelastine Impurity 34 (CAS 1878-66-6)
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- 1,3-Dichloro-2-iodo-5-(trifluoromethoxy)benzene (CAS 1414870-80-6)
- 1-tert-butyl 3-methyl 4-methylpiperazine-1,3-dicarboxylate (CAS 1285898-99-8)
- 1-(2-Hydroxyethyl)-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (CAS 67056-25-1)
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- 4-(((2,4-Diaminopteridin-6-yl)methyl)(prop-2-yn-1-yl)amino)benzoic acid (CAS 111854-71-8)
- D-Glu3-Tirzepatide (CAS CATO-CPTD788927)
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