Ponatinib Impurity 19 CAS CATO-C4X-226919
| CAS No. | CATO-C4X-226919 |
| Molecular Formula | C21H19N3O3 |
| Molecular Weight | 361.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Ponatinib Impurity 19 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 361.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ponatinib Impurity 19 (CAS CATO-C4X-226919, C21H19N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ponatinib Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19N3O3 |
| Molecular Weight | 361.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Ponatinib Standards
- Ponatinib impurity 5 (CAS 122947-77-7)
- Ponatinib Impurity 34 (CAS CATO-C4X-226934)
- Ponatinib Impurity 16 (CAS CATO-C4X-226916)
- Ponatinib Impurity 45 (CAS CATO-C4X-226945)
- Ponatinib Impurity 31 (CAS CATO-C4X-226931)
- Ponatinib Impurity 9 (CAS CATO-C4X-22699)
- Ponatinib Impurity 42 (CAS CATO-C4X-226942)
- Ponatinib Impurity N72 (CAS 957147-18-1)
Recommended Standards
- Polmacoxib (CAS 301692-76-2)
- Isoprenaline Impurity 26 (CAS CATO-C4X-277526)
- Bisacodyl EP Impurity E (CAS 111664-35-8)
- Ozanimod Impurity 21 (CAS 1201447-05-3)
- Oxacillin Impurity 29 (CAS CATO-C4X-232129)
- Labetalol Impurity 8 (CAS 36256-45-8)
- Ixazomib Impurity 52 (CAS CATO-C4X-126752)
- Glecaprevir (CAS 1365970-03-1)
- 5-Cyclopropoxy-2-(methylthio)aniline (CAS 1243455-01-7)
- Ambroxol Impurity 93 (CAS CATO-C4X-108593)
- 1H-Pyrazolo[3,4-d]pyrimidine-3-carbonitrile, 6-amino-4-chloro-1-methyl- (CAS 2935432-21-4)
- (4-Nitrophenyl)methylrel-(1r,4r)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptane-5-carboxylate (CAS 1638771-19-3)
- Ethyl 4-hydrazinyl-3-nitrobenzoate (CAS 355425-79-5)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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