Lifitegrast Impurity 81 CAS CATO-C4X-240981
| CAS No. | CATO-C4X-240981 |
| Molecular Formula | C29H22Cl2N2O9S |
| Molecular Weight | 645.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Lifitegrast Impurity 81 (CAS CATO-C4X-240981) is a certified pharmaceutical impurity reference standard with the molecular formula C29H22Cl2N2O9S and a molecular weight of 645.46 g/mol.
Based on its molecular formula C29H22Cl2N2O9S, Lifitegrast Impurity 81 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 645.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C29H22Cl2N2O9S |
| Molecular Weight | 645.46 g/mol |
| Purity | ＞95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- lifitegrast Impurity 20 (CAS 2295862-24-5)
- Lifitegrast Impurity 80 (CAS CATO-C4X-240980)
- Lifitegrast impurity 95 (CAS CATO-C4X-240995)
- Lifitegrast Impurity 140 (CAS CATO-C4X-2409140)
- Lifitegrast Impurity 3 (CAS CATO-C4X-24093)
- Lifitegrast Impurity 121 (CAS CATO-C4X-2409121)
- Lifitegrast Impurity 58 (CAS CATO-C4X-240958)
- Lifitegrast Impurity 7 (CAS CATO-C4X-24097)
Recommended Standards
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