Lifitegrast Impurity 3 CAS CATO-C4X-24093
| CAS No. | CATO-C4X-24093 |
| Molecular Formula | C28H24Cl2N2O9S |
| Molecular Weight | 635.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lifitegrast Impurity 3 (C28H24Cl2N2O9S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lifitegrast Impurity 3 (CAS CATO-C4X-24093, C28H24Cl2N2O9S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H24Cl2N2O9S |
| Molecular Weight | 635.47 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 140 (CAS CATO-C4X-2409140)
- Lifitegrast Impurity 121 (CAS CATO-C4X-2409121)
- Lifitegrast Impurity 58 (CAS CATO-C4X-240958)
- Lifitegrast Impurity 7 (CAS CATO-C4X-24097)
- Lifitegrast Impurity 82 (CAS CATO-C4X-240982)
- Lifitegrast Impurity 90 (CAS CATO-C4X-240990)
- Lifitegrast Impurity 122 (CAS CATO-C4X-2409122)
- Lifitegrast Impurity 35 (CAS 2295862-29-0)
Recommended Standards
- 3-Chloro-2-({5-[(1E)-1-[(E)-2-[1-(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)ethylidene]hydrazin-1-ylidene]ethyl]thiophen-2-yl}methyl)-5-(trifluoromethyl)pyridine (CAS 321432-69-3)
- (2S,3S)-N2-(4-(Benzo[d]thiazol-2-ylcarbamoyl)phenyl)-N3-(3,4-dichlorophenyl)-N2-(4-fluorobenzyl)oxirane-2,3-dicarboxamide (CAS 1639140-80-9)
- rac-1,2-Dilinoleoyl-3-chloropropanediol (CAS 74875-96-0)
- Bis(dicyclohexylphenylphosphine)(η2-ethene)nickel (CAS 1419179-27-3)
- Leflunomide Impurity 14 (CAS 51145-57-4)
- Ertapenem Impurity 53 (CAS CATO-C4X-163353)
- Levothyroxine Impurity 27 (CAS 671235-41-9)
- Solifenacin Impurity 34 (CAS 1243274-81-8)
- 6-Bromo-8-(2-fluorobenzyl)imidazo[1,2-a]pyrazine (CAS 2201049-52-5)
- 6-Methoxy-2-(trifluoromethyl)-1H-indole (CAS 174907-38-1)
- 6-Methoxy-1-methyl-1H-indole-3-carbaldehyde (CAS 202807-44-1)
- 1-(Difluoromethoxy)-2-(difluoromethyl)benzene (CAS 1214350-08-9)
- Tert-butyl (3S,4R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 2306245-05-4)
- 81988-89-8 UH11FDQ454 Ramoplanin A(sub 3) Ramoplanin A3 (S)-2-(3-Chloro-4-hydroxyphenyl)-N-(N(sup 2)-((2Z,4Z)-8-methyl-2,4-nonadienoyl)-(S)-asparaginyl-(2S,3S)-3-hydroxyasparaginyl-(R)-2-(p-hydroxyphenyl)glycyl-(R)-ornithyl-(2R,3R)-allothreonyl-2-(p-hydroxyphenyl)glycyl-2-(p-hydroxyphenyl)glycyl-(2S,3S)-allothreonyl-(S)-phenylalanyl-(R)-ornithyl-(S)-2-(p-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycyl-(2R,3R)-allothreonyl-(S)-2-(p-hydroxyphenyl)glycylglycyl-(S)-leucyl-(R)-alanyl)glycine psi1-lactone Ramoplanin A 1 (peptide moiety), 1-(N(sup 2)-methyl-1-oxo-2,4-nonadienyl)-L-asparagine)-11-(L-2-(4-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycine)-, (Z,Z)- UNII-UH11FDQ454 (CAS 81988-89-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com