Perampanel Impurity 8 CAS CATO-C4X-24308
| CAS No. | CATO-C4X-24308 |
| Molecular Formula | C16H11BrN2O2 |
| Molecular Weight | 343.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Perampanel Impurity 8.
As a process- or degradation-related impurity, Perampanel Impurity 8 (CAS CATO-C4X-24308, C16H11BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Perampanel Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11BrN2O2 |
| Molecular Weight | 343.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Perampanel Standards
- Perampanel Impurity 22 (CAS CATO-C4X-243022)
- Perampanel Impurity 20 (CAS 2137956-02-4)
- Perampanel Impurity 33 (CAS CATO-C4X-243033)
- Perampanel Impurity 46 (CAS CATO-C4X-243046)
- Perampanel impurity 47 (CAS CATO-C4X-243047)
- Perampanel Impurity 31 (CAS CATO-C4X-243031)
- Perampanel Impurity 4 (CAS 380918-53-6)
- Perampanel Impurity 5 (CAS 380918-54-7)
Recommended Standards
- N-Nitroso Resmetirom impurity 141 (CAS CATO-C4X-2912141)
- Roxadustat Impurity 142 (CAS CATO-C4X-2213142)
- N-(5-Amino-2-fluorophenyl)-2-(2,4-dichlorophenoxy)propanamide (CAS 1020056-48-7)
- Dihydralazine Impurity 5 (CAS CATO-C4X-20785)
- Palbociclib Impurity 20 (CAS CATO-C4X-112520)
- Ornidazole Impurity 64 (CAS CATO-C4X-133164)
- Tofacitinib Nitroso Impurity 189 (CAS CATO-C4X-1079189)
- Ethyl 5,6-dihydro-4H-pyrrolo[3,4-d]oxazole-2-carboxylate hydrochloride (CAS 2177257-76-8)
- 1-benzyl-3-tert-butylpyrrolidine-3-carbaldehyde (CAS 2059936-27-3)
- (4-{[2-(Trimethylsilyl)ethoxy]carbonyl}phenyl)boronic acid (CAS 2377605-86-0)
- 1-[(3-Phenoxyphenyl)methyl]piperazine (CAS 114010-96-7)
- Iguratimod Impurity 4 (CAS 84594-95-6)
- (R)-1-Phenylpentan-1-amine (CAS 105370-59-0)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
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