Rimegepant Impurity 32 CAS CATO-C4X-248732
| CAS No. | CATO-C4X-248732 |
| Molecular Formula | C28H26F2N8O3 |
| Molecular Weight | 560.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Rimegepant Impurity 32 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Rimegepant Impurity 32 (CAS CATO-C4X-248732, C28H26F2N8O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Rimegepant Impurity 32 (C28H26F2N8O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H26F2N8O3 |
| Molecular Weight | 560.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Rimegepant Standards
- Rimegepant Impurity 107 (CAS CATO-C4X-2487107)
- Rimegepant Impurity 131 (CAS CATO-C4X-2487131)
- Rimegepant Impurity 68 (CAS CATO-C4X-248768)
- Rimegepant Impurity 109 (CAS CATO-C4X-2487109)
- Rimegepant Impurity 117 (CAS CATO-C4X-2487117)
- Rimegepant Impurity 161 (CAS CATO-C4X-2487161)
- Rimegepant Impurity 69 (CAS CATO-C4X-248769)
- Rimegepant Impurity 7 (CAS CATO-C4X-24877)
Recommended Standards
- N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide (CAS 1361030-48-9)
- Ethyl 4-cyano-5-(2-((3-cyano-6-(4-methoxyphenyl)-4-(trifluoromethyl)pyridin-2-yl)thio)acetamido)-3-methylthiophene-2-carboxylate (CAS 498537-21-6)
- Dutasteride Impurity 26 (CAS CATO-C4X-110326)
- Levosimendan Impurity 32 (CAS CATO-C4X-130832)
- Bisacodyl Impurity 8 (CAS CATO-C4X-20378)
- Minoxidil Impurity 43 HCl (CAS 1799434-61-9)
- Bromocriptine Impurity 18 (CAS CATO-C4X-136118)
- 1-(5-Bromo-4-chloro-2-fluorophenyl)ethanone (CAS 1704367-12-3)
- 2,3-Dimethylbutyl Chloroformate (CAS 1215109-12-8)
- 2,3-Dihydro-1-benzofuran-3-carbonyl chloride (CAS 1343949-08-5)
- 1-(2-(Phenylthio)ethyl)-1h-1,2,3-triazol-4-amine (CAS 1505443-24-2)
- 2-(4,4-Dimethylpyrrolidin-2-ylidene)-1-phenylethanone (CAS 61856-64-2)
- 1-(tert-Butyl)-1H-pyrrol-2-amine (CAS 173853-67-3)
- Insulin Glargine (CAS 160337-95-1)
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