Rimegepant Impurity 80 CAS CATO-C4X-248780
| CAS No. | CATO-C4X-248780 |
| Molecular Formula | C25H33F2NO2Si |
| Molecular Weight | 445.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rimegepant Impurity 80.
Rimegepant Impurity 80 (CAS CATO-C4X-248780) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33F2NO2Si and a molecular weight of 445.62 g/mol.
The molecular framework of Rimegepant Impurity 80 (C25H33F2NO2Si) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H33F2NO2Si |
| Molecular Weight | 445.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 14 (CAS 1397526-07-6)
- Rimegepant Impurity 143 (CAS CATO-C4X-2487143)
- Rimegepant Impurity 15 (CAS CATO-C4X-248715)
- Rimegepant Impurity 16 (CAS 1397526-11-2)
- Rimegepant Impurity 9 (CAS 1190363-46-2)
- Rimegepant Impurity 111 (CAS CATO-C4X-2487111)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
Recommended Standards
- N-((2R,3R,4R,5S,6R)-2-(hexadecyloxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 115414-49-8)
- 1-O-Benzoyl C2 Ceramide (CAS 78715-90-9)
- [S(R)]-N-[(1R)-1-[2-(Di-tert-butylphosphanyl)phenyl]phenylmethyl]-N,2-dimethyl-2-propanesulfinamide (CAS 2757083-12-6)
- 3,3'-Dihexyloxacarbocyanine (CAS 54501-79-0)
- Dopamine Impurity 117 (CAS CATO-C4X-1908117)
- Indocyanine Green Impurity 8 (CAS 63450-66-8)
- Melatonin impurity 14 (CAS 67199-08-0)
- Borane dimethyl sulfide complex (CAS 13292-87-0)
- 5-(Isocyanatomethyl)-2H-1,3-benzodioxole (CAS 71217-46-4)
- 5-Chloro-3-ethyl-1-(2-fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 1152583-51-1)
- 3-Bromo-4-cyano-5-nitrobenzenesulfonyl chloride (CAS 1805102-35-5)
- 2-(4-Bromo-2-fluorophenyl)-4-chloro-6-methylpyrimidine (CAS 1395552-37-0)
- 6-Hydroxy-2-thioxo-5-(p-tolyldiazenyl)-2,3-dihydropyrimidin-4(1H)-one (CAS 36137-21-0)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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