Rimegepant Impurity 81 CAS CATO-C4X-248781
| CAS No. | CATO-C4X-248781 |
| Molecular Formula | C28H53NO2Si2 |
| Molecular Weight | 491.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Rimegepant Impurity 81 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Rimegepant Impurity 81 (CAS CATO-C4X-248781) is a certified pharmaceutical impurity reference standard with the molecular formula C28H53NO2Si2 and a molecular weight of 491.90 g/mol.
The molecular framework of Rimegepant Impurity 81 (C28H53NO2Si2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H53NO2Si2 |
| Molecular Weight | 491.90 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 121 (CAS CATO-C4X-2487121)
- Rimegepant Impurity 148 (CAS CATO-C4X-2487148)
- Rimegepant Impurity 97 (CAS CATO-C4X-248797)
- Rimegepant Impurity 103 (CAS CATO-C4X-2487103)
- Rimegepant Impurity 104 (CAS 1356400-55-9)
- Rimegepant Impurity 26 (CAS 1289024-05-0)
- Rimegepant Impurity 30 (CAS CATO-C4X-248730)
- Rimegepant Impurity 45 (CAS CATO-C4X-248745)
Recommended Standards
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