Dotinurad Impurity 158 CAS CATO-C4X-2494158
| CAS No. | CATO-C4X-2494158 |
| Molecular Formula | C22H15Cl4NO6S |
| Molecular Weight | 563.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dotinurad Impurity 158.
As a process- or degradation-related impurity, Dotinurad Impurity 158 (CAS CATO-C4X-2494158, C22H15Cl4NO6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Dotinurad Impurity 158 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 563.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H15Cl4NO6S |
| Molecular Weight | 563.23 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Dotinurad Standards
- Dotinurad Impurity 113 (CAS CATO-C4X-2494113)
- Dotinurad Impurity 92 (CAS CATO-C4X-249492)
- Dotinurad Impurity 250 (CAS CATO-C4X-2494250)
- Dotinurad Impurity 201 (CAS CATO-C4X-2494201)
- Dotinurad Impurity 206 (CAS CATO-C4X-2494206)
- Dotinurad Impurity 200 (CAS CATO-C4X-2494200)
- Dotinurad Impurity 18 (CAS CATO-C4X-249418)
- Dotinurad Impurity 262 (CAS CATO-C4X-2494262)
Recommended Standards
- Metoclopramide Impurity 83 (CAS 1242047-99-9)
- 5-[3-[(Aminoiminomethyl)amino]-1-propynyl]-2'-deoxy-uridine 5'-(tetrahydrogen triphosphate) (CAS 402932-20-1)
- Metoclopramide impurity 56 (CAS 1242048-03-8)
- 2,7-Dibromospiro[fluorene-9,8'-indolo[3,2,1-de]acridine] (CAS 902525-12-6)
- Relugolix Impurity 91 (CAS CATO-C4X-242991)
- Clevidipine Butyrate impurity 19 (CAS 253597-20-5)
- Enalapril Maleate Impurity 25 (CAS CATO-C4X-133425)
- N-(4-((3-Aminoacridin-9-yl)amino)phenyl)benzamide (CAS 76015-28-6)
- 2-Chloro-7-nitro-1H-benzo[d]imidazole (CAS 15965-55-6)
- 1-BOC-4-(4-PYRIDINYLCARBONYL)-PIPERAZINE (CAS 163838-89-9)
- 5,7-Dimethoxy-3-(1-naphthoyl)coumarin (CAS 86548-40-5)
- Methyl 3-(bromomethyl)-2-phenylquinoline-4-carboxylate (CAS 272104-64-0)
- 1-Benzyloctahydropyrrolo[3,4-b]pyrrole (CAS 132414-50-7)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
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