Thiophene impurity 5 CAS CATO-C4X-25475
| CAS No. | CATO-C4X-25475 |
| Molecular Formula | C5H4O3S |
| Molecular Weight | 144.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Thiophene impurity 5.
Thiophene impurity 5 (CAS CATO-C4X-25475) is a certified pharmaceutical impurity reference standard with the molecular formula C5H4O3S and a molecular weight of 144.15 g/mol.
Structurally, Thiophene impurity 5 (C5H4O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 144.15 g/mol, it falls into the low-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4O3S |
| Molecular Weight | 144.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Sulfur Atoms | 1 |
Related Thiophene Standards
- Thiophene-2,3-dimethanol (CAS 13250-85-6)
- thiophene-2,4-dicarbaldehyde (CAS 932-93-4)
- Thiophene-2,5-diyldimethanol (CAS 6007-86-9)
- 932-95-6 A844510 thiophene-2,5-dicarbaldehyde thiophene-2,5-dicarboxaldehyde (CAS 932-95-6)
- Thiophene-2,5-diyldimethanamine (CAS 13752-93-7)
- thiophene-3-carbohydrazide (CAS 39001-23-5)
- Thiophene-3-carbothioic acid amide thiophene-3-thioamide thiophene-3-thiocarboxamide thiophene-3-carbothioamide 3-Thiophenethiocarboxamide 24044-76-6 (CAS 24044-76-6)
- Thiophene-3,4-dicarbaldehyde (CAS 1073-31-0)
Recommended Standards
- Acotiamide Impurity 41 (CAS 40283-41-8)
- Dimetridazole-d3 (CAS 64678-69-9)
- Ticagrelor Impurity 137 (CAS 504-17-6)
- 4-ethynyl-1,1-difluorocyclohexane (CAS 1202245-66-6)
- Finerenone Impurity 77 (CAS CATO-C4X-288077)
- Metoclopramide EP Impurity G (CAS 171367-22-9)
- Tegoprazan Impurity 97 (CAS CATO-C4X-229797)
- 7-Fluorobenzo[b]thiophen-3(2H)-one (CAS 1558342-18-9)
- Methyl 8-hydroxyquinoline-2-carboxylate (CAS 21638-90-4)
- 3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-a]isoquinoline (CAS 27022-50-0)
- 3-(6-Oxo-1H-purin-9(6H)-yl)propanehydrazide (CAS 95789-94-9)
- 2-{[(4-bromo-2,5-dimethoxyphenyl)amino]methylidene}-5,5-dimethylcyclohexane-1,3-dione (CAS 1024165-45-4)
- 5-(2-(2,6-Dimethylphenyl)hydrazinyl)-3,4-dihydro-2H-pyrrole (CAS 802617-97-6)
- Exenatide (CAS 141758-74-9)
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