Thiophene impurity 6 CAS CATO-C4X-25476
| CAS No. | CATO-C4X-25476 |
| Molecular Formula | C5H4O4S |
| Molecular Weight | 160.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Thiophene impurity 6.
As a process- or degradation-related impurity, Thiophene impurity 6 (CAS CATO-C4X-25476, C5H4O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Thiophene impurity 6 (C5H4O4S) contains a carbohydrate-derived structure, a sulfone group. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 160.15 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4O4S |
| Molecular Weight | 160.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Sulfur Atoms | 1 |
Related Thiophene Standards
- Thiophene-3-carboxylic acid 1,1-dioxide (CAS 1858240-97-7)
- 2,2'-(Thiophene-2,3-diyl)diacetonitrile (CAS 38447-33-5)
- 2,2'-(Thiophene-2,5-diyl)diacetonitrile (CAS 702-22-7)
- 2,2'-(Thiophene-3,4-diyl)diacetonitrile (CAS 38447-32-4)
- Thiophene-3-sulfonamide (CAS 64255-63-6)
- Ethyl thiophene-2-carboxylate (CAS 2810-04-0)
- Ethyl Thiophene-3-carboxylate (CAS 5751-80-4)
- Thiophene-2-sulfonic acid (CAS 79-84-5)
Recommended Standards
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- 1-(2,2-difluoroethyl)-3,5-dimethyl-1h-pyraZole (CAS 1006959-46-1)
- Vortioxetine Impurity 67 (CAS CATO-C4X-105667)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
- Paclitaxel Impurity 60 (CAS CATO-C4X-184260)
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- 2-(4-Butylphenyl)propan-2-ol (CAS 1204242-91-0)
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- Isopropyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 301233-27-2)
- Benzo[c][1,2,5]thiadiazol-5-yl(1,5-dioxa-9-azaspiro[5.5]undecan-9-yl)methanone (CAS 1351618-77-3)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
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