Tucatinib Impurity 11 CAS CATO-C4X-260511
| CAS No. | CATO-C4X-260511 |
| Molecular Formula | C12H16N4OS |
| Molecular Weight | 264.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tucatinib Impurity 11 (CAS CATO-C4X-260511, C12H16N4OS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H16N4OS, Tucatinib Impurity 11 contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 264.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16N4OS |
| Molecular Weight | 264.35 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Tucatinib Standards
- Tucatinib Impurity 37 (CAS CATO-C4X-260537)
- Tucatinib Impurity 38 (CAS CATO-C4X-260538)
- Tucatinib Impurity 47 (CAS CATO-C4X-260547)
- Tucatinib Impurity 57（E-Isomer） (CAS CATO-C4X-260557)
- Tucatinib Impurity 53 (CAS CATO-C4X-260553)
- Tucatinib Impurity 35 (CAS CATO-C4X-260535)
- Tucatinib Impurity 70 (CAS CATO-C4X-260570)
- Tucatinib Impurity 9 (CAS CATO-C4X-26059)
Recommended Standards
- Thiamine /Vitamin B1 Impurity 46 (CAS CATO-C4X-187346)
- 2-(3-Methoxybenzylidene)-5-(methylthio)thiophen-3(2H)-one (CAS 1000574-08-2)
- n-(2-Morpholinoethyl)thieno[2,3-d]pyrimidin-4-amine (CAS 851898-21-0)
- 2-(4-Methoxyphenyl)-6-(methylthio)-4H-thiopyran-4-one (CAS 1000574-20-8)
- Cefamandole Nafate EP Impurity D (CAS 13183-79-4)
- Progesterone Impurity 61 (CAS CATO-C4X-150261)
- Amorolfine EP Impurity D HCl (CAS 67306-03-0（free base）)
- 6-Chloro-7-isopropyl-7H-purin-8(9H)-one (CAS 1226804-22-3)
- 2-Propyl-1,3-thiazolidine (CAS 24050-10-0)
- 1007-55-2 6-Chloro-N-isopropylpyridazin-3-amine 7262AC C7H10ClN3 (CAS 1007-55-2)
- Glyceryl-d5 Trihexadecanoate (CAS 60763-98-6)
- N-Desmethyl Dextrorphan -β-D-O-Glucuronide (CAS 19153-89-0)
- N-Benzyl-2-(4-phenylpiperazin-1-yl)quinazolin-4-amine (CAS 166039-49-2)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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