Pretomanid Impurity 9 CAS CATO-C4X-26069
| CAS No. | CATO-C4X-26069 |
| Molecular Formula | C13H10F3N3O5 |
| Molecular Weight | 345.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pretomanid Impurity 9 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Pretomanid Impurity 9 (CAS CATO-C4X-26069) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10F3N3O5 and a molecular weight of 345.23 g/mol.
Structurally, Pretomanid Impurity 9 (C13H10F3N3O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 345.23 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10F3N3O5 |
| Molecular Weight | 345.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Pretomanid Standards
- Pretomanid Impurity 22 (CAS CATO-C4X-260622)
- Pretomanid Impurity 25 (CAS CATO-C4X-260625)
- Pretomanid Impurity 18 (CAS CATO-C4X-260618)
- Pretomanid Impurity 3 (CAS 2755727-09-2)
- Pretomanid (CAS 187235-37-6)
- Pretomanid Impurity 15 (CAS 1353753-57-7)
- Pretomanid Impurity 16 (CAS CATO-C4X-260616)
- Pretomanid Impurity 2 (CAS 1105708-11-9)
Recommended Standards
- Varenicline Impurity 20 (CAS 230615-59-5)
- Ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)glycinate (CAS 1092460-58-6)
- Daclatasvir Impurity 2 (CAS CATO-C4X-18482)
- N-(2-Bromophenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142200-07-4)
- Testosterone Impurity 25 (CAS CATO-C4X-132625)
- Vibegron Impurity 19 (CAS 136620-82-1)
- Lurasidone Impurity 39 (CAS 7716-66-7)
- 3-((2-Amino-6-oxo-1H-purin-9(6H)-yl)oxy)propyl acetate (CAS 114778-61-9)
- 6-Bromo-2,3-dihydro-imidazo[1,2-a]pyridine (CAS 793628-63-4)
- (Benzo[d][1,3]dioxol-5-ylmethyl)triphenylphosphonium chloride (CAS 63368-35-4)
- R-Cefadroxil Sulfoxide (CAS CATO-C4X-122415)
- Cycloicosanone (CAS 6907-39-7)
- Dimethylsulfonioproprionate (CAS 7314-30-9)
- Palmitoyl Pentapeptide-4 (CAS 214047-00-4)
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