Ramelteon impurity 45 CAS CATO-C4X-262245
| CAS No. | CATO-C4X-262245 |
| Molecular Formula | C20H21NO2 |
| Molecular Weight | 307.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ramelteon impurity 45 (CAS CATO-C4X-262245) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21NO2 and a molecular weight of 307.39 g/mol.
The molecular framework of Ramelteon impurity 45 (C20H21NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21NO2 |
| Molecular Weight | 307.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Ramelteon Standards
- Ramelteon Impurity 53 (CAS CATO-C4X-262253)
- Ramelteon RC 9 (CAS 196597-84-9)
- Ramelteon Impurity 40 (CAS 1346598-94-4)
- Ramelteon Impurity 32 (CAS CATO-C4X-262232)
- Ramelteon Impurity 60 (CAS CATO-C4X-262260)
- Ramelteon Impurity 51 (CAS 896736-20-2)
- Ramelteon Impurity 47 (CAS CATO-C4X-262247)
- Ramelteon Impurity K (CAS 196597-77-0)
Recommended Standards
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- Baxdrostat Impurity 30 (CAS 1428651-83-5)
- Tizanidine EP Impurity C (CAS 1147548-83-1)
- 【停用，见C4X-187758】Pyridoxine impurity 71 (CAS CATO-C4X-187771)
- Afatinib Impurity 13 (CAS CATO-C4X-100613)
- 3-(1-Amino-2,2,2-trifluoroethyl)bicyclo[1.1.1]pentan-1-amine hydrochloride (CAS 2830579-48-9)
- 5-(4-Bromo-2-chlorophenyl)-1,3,4-oxadiazol-2-amine (CAS 1157719-91-9)
- Trazodone impurity 57 (CAS CATO-C4X-177257)
- 5-Fluoro-4-formylpicolinic acid (CAS 1289040-31-8)
- 1-[4-(difluoromethoxy)phenyl]piperidin-4-amine (CAS 1094308-87-8)
- 3-Morpholinopropanimidamide (CAS 1016791-67-5)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
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