Icotinib Impurity 3 CAS CATO-C4X-27673

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-27673
Molecular FormulaC22H21N3O5
Molecular Weight407.42 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Icotinib Impurity 3 CAS CATO-C4X-27673 chemical structure

Description

CATO supplies Icotinib Impurity 3 (CAS CATO-C4X-27673), a pharmacopoeial impurity reference standard (molecular formula C22H21N3O5, MW 407.42 g/mol) used for the identification and quantification of trace impurities in APIs.

Icotinib Impurity 3 (C22H21N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Icotinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC22H21N3O5
Molecular Weight407.42 g/mol
AppearancePale yellow to yellow crystalline powder
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Nitrogen Atoms3

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