Abrocitinib Impurity 45 CAS CATO-C4X-288445
| CAS No. | CATO-C4X-288445 |
| Molecular Formula | C22H37N7O4S2 |
| Molecular Weight | 527.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 527.70 g/mol gives Abrocitinib Impurity 45 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Abrocitinib Impurity 45 (CAS CATO-C4X-288445, C22H37N7O4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abrocitinib Impurity 45 (C22H37N7O4S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abrocitinib Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H37N7O4S2 |
| Molecular Weight | 527.70 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 2 |
Related Abrocitinib Standards
- Abrocitinib Impurity 40 (CAS CATO-C4X-288440)
- Abrocitinib Impurity 38 (CAS CATO-C4X-288438)
- Abrocitinib Impurity 23 (CAS 2204275-76-1)
- Abrocitinib Impurity 47 (CAS CATO-C4X-288447)
- Abrocitinib Impurity 44 (CAS CATO-C4X-288444)
- Abrocitinib Impurity 51 (CAS CATO-C4X-288451)
- Abrocitinib Impurity 42 (CAS CATO-C4X-288442)
- Abrocitinib Impurity 34 (CAS CATO-C4X-288434)
Recommended Standards
- (R)-N-((S)-(4-(tert-butyl)phenyl)(2-(diphenylphosphanyl)phenyl)methyl)-2-methylpropane-2-sulfinamide (CAS 2628235-12-9)
- (1R,2S,5S)-3-((S)-2-(3-(1-(tert-butylsulfonylmethyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (CAS 1229337-32-9)
- (S)-3-(2-(2-aminopropanamido)-4-(tert-butoxy)phenyl)-N-(2,2-diethoxyethyl)-N-phenethylpropanamide (CAS 1222068-59-8)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
- Isavuconazole Impurity 235 (CAS CATO-C4X-1236235)
- Ruxolitinib Impurity 124 (CAS CATO-C4X-2058124)
- Nimodipine impurity 22 (CAS CATO-C4X-138522)
- (S)-4-((3,3-Dimethyloxiran-2-yl)methoxy)-7H-furo[3,2-g]chromen-7-one (CAS 26091-73-6)
- 2-(2-Fluoro-6-(trifluoromethyl)phenyl)acetic acid (CAS 179946-32-8)
- 3-[4-(1,1-Dimethylheptyl)-2-(phenylmethoxy)phenyl]cyclohexanone (CAS 70434-13-8)
- 5-Methoxy-3-phenylbenzoic acid (CAS 1214369-81-9)
- Quinoline-6-carbothioamide (CAS 855763-64-3)
- 1-(2-Methoxyethyl)-2-pyrrolidinone (CAS 51576-82-0)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
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