Abrocitinib Impurity 38 CAS CATO-C4X-288438
| CAS No. | CATO-C4X-288438 |
| Molecular Formula | C20H22Cl2N8O2S |
| Molecular Weight | 509.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Abrocitinib Impurity 38 (C20H22Cl2N8O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Abrocitinib Impurity 38 (CAS CATO-C4X-288438, C20H22Cl2N8O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H22Cl2N8O2S |
| Molecular Weight | 509.41 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 1 |
Related Abrocitinib Standards
- Abrocitinib Impurity 45 (CAS CATO-C4X-288445)
- Abrocitinib Impurity 40 (CAS CATO-C4X-288440)
- Abrocitinib Impurity 23 (CAS 2204275-76-1)
- Abrocitinib Impurity 44 (CAS CATO-C4X-288444)
- Abrocitinib Impurity 51 (CAS CATO-C4X-288451)
- Abrocitinib Impurity 42 (CAS CATO-C4X-288442)
- Abrocitinib Impurity 47 (CAS CATO-C4X-288447)
- Abrocitinib Impurity 34 (CAS CATO-C4X-288434)
Recommended Standards
- Aprepitant Impurity 69 (CAS 178616-88-1)
- 2-((4-(4-Bromophenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(dimethylamino)phenyl)acetamide (CAS 477329-61-6)
- Arbidol Sulfone (CAS 151455-32-2)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(dimethylamino)phenyl)acetamide (CAS 477330-35-1)
- Prilocaine Impurity 12 (CAS 19422-76-5)
- Orforglipron impurity 75 (CAS CATO-C4X-323475)
- Omeprazole Impurity 55 (CAS 58469-06-0)
- 4,4-Dimethylpentanoic acid (CAS 1118-47-4)
- 1-Ethyl-N-(5-methylisoxazol-3-yl)-1H-pyrazole-4-carboxamide (CAS 515122-60-8)
- Tetrabutylammonium bibenzoate (CAS 116263-39-9)
- 9-(4-(4,6-Diphenyl-1,3,5-triazin-2-yl)phenyl)-9H-carbazole (CAS 440354-93-8)
- 1-Ethyl-3-(pyridin-3-yl)urea (CAS 20949-54-6)
- 1-(L-leucyl)piperidine-4-carboxylic acid (CAS 1308930-89-3)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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