Resmetirom Impurity 10 CAS CATO-C4X-291210
| CAS No. | CATO-C4X-291210 |
| Molecular Formula | C18H16Cl2N6O4 |
| Molecular Weight | 451.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Resmetirom Impurity 10 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Resmetirom Impurity 10 (CAS CATO-C4X-291210), a pharmacopoeial impurity reference standard (molecular formula C18H16Cl2N6O4, MW 451.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Resmetirom Impurity 10 (C18H16Cl2N6O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Resmetirom Impurity 10 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H16Cl2N6O4 |
| Molecular Weight | 451.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 137 (CAS CATO-C4X-2912137)
- Resmetirom impurity 132 (CAS 2542038-65-1)
- Resmetirom Impurity 26 (CAS 2222607-69-2)
- Resmetirom impurity 109 (CAS CATO-C4X-2912109)
- Resmetirom impurity 14 (CAS 2542029-02-5)
- Resmetirom impurity 17 (CAS 2403721-20-8)
- Resmetirom impurity 15 (CAS 920509-35-9)
- Resmetirom Impurity 51 (CAS CATO-C4X-291251)
Recommended Standards
- Ethyl 3-(2-(4-iodophenyl)-5-methyl-7-oxo-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)propanoate (CAS 6048-49-3)
- tert-Butyl 7-(benzyloxy)-5-iodo-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylate (CAS 1262132-97-7)
- 2-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-oxoethyl 2-bromo-5-methoxybenzoate (CAS 875157-56-5)
- Methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-iodopropanoate (CAS 527696-77-1)
- Solifenacin Impurity 34 (CAS 1243274-81-8)
- Doxofylline Impurity 43 (CAS CATO-C4X-151343)
- Cefixime Impurity 51 (CAS CATO-C4X-113951)
- Sulindac Impurity N93 (CAS 55707-59-0)
- (2,3-Difluorophenyl)methanethiol (CAS 412950-51-7)
- 3,5-Dibromo-2,4,6-trifluorobenzoic acid (CAS 1951439-80-7)
- n-(1-(1h-Pyrazol-1-yl)propan-2-yl)-5-bromofuran-2-carboxamide (CAS 1170023-15-0)
- Levomenol (CAS 23089-26-1)
- Milnacipran-d5 HCl (and Enantiomer) (CAS 2750534-79-1)
- Semaglutide Impurity 5 (CAS 23406-82-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com