Resmetirom Impurity 100 CAS CATO-C4X-2912100
| CAS No. | CATO-C4X-2912100 |
| Molecular Formula | C15H17Cl2N3O2 |
| Molecular Weight | 342.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom Impurity 100.
As a process- or degradation-related impurity, Resmetirom Impurity 100 (CAS CATO-C4X-2912100, C15H17Cl2N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H17Cl2N3O2, Resmetirom Impurity 100 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 342.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom Impurity 100 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H17Cl2N3O2 |
| Molecular Weight | 342.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥98% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 127 (CAS CATO-C4X-2912127)
- Resmetirom impurity 131 (CAS 2768216-97-1)
- Resmetirom impurity 82 (CAS CATO-C4X-291282)
- Resmetirom Impurity 48 (CAS CATO-C4X-291248)
- Resmetirom Impurity 102 (CAS CATO-C4X-2912102)
- Resmetirom impurity 103 (CAS CATO-C4X-2912103)
- Resmetirom Impurity 30 (CAS CATO-C4X-291230)
- Resmetirom Impurity 5 (CAS 920509-27-9)
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- (Orn8)-Triptorelin TFA salt (CAS CATO-C4X-186215)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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