Letermovir Impurity 45 CAS CATO-C4X-291545
| CAS No. | CATO-C4X-291545 |
| Molecular Formula | C28H26F4N4O4 |
| Molecular Weight | 558.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Letermovir Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Letermovir Impurity 45 (CAS CATO-C4X-291545, C28H26F4N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Letermovir Impurity 45 (C28H26F4N4O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C28H26F4N4O4 |
| Molecular Weight | 558.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Letermovir Standards
- Letermovir Impurity 29 (CAS CATO-C4X-291529)
- Letermovir Impurity 26 (CAS CATO-CP155163)
- Letermovir Impurity 4 (CAS CATO-CP155165)
- Letermovir Impurity 31 (CAS CATO-C4X-291531)
- Letermovir Impurity 77 (CAS CATO-C4X-291577)
- Letermovir Impurity 33 (CAS CATO-C4X-291533)
- Letermovir impurity 110 (CAS CATO-C4X-2915110)
- Letermovir impurity 125 (CAS CATO-C4X-2915125)
Recommended Standards
- N2,N4,N6-Tris(4-(2H-tetrazol-5-yl)phenyl)-1,3,5-triazine-2,4,6-triamine (CAS 2410710-17-5)
- (3S)-tert-butyl 3-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate (CAS 868565-58-6)
- 4',5'-Bis(4-carboxyphenyl)-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid (CAS 1078153-58-8)
- Nilotinib Impurity 39 (CAS 2925306-68-7)
- Rivaroxaban impurity 174 (CAS CATO-C4X-1090174)
- Selexipag Impurity 33 (CAS CATO-C4X-196133)
- Betamethasone impurity 44 (CAS CATO-C4X-143744)
- 3-Ethyl-4-(thiophen-2-yl)-1h-pyrazol-5-amine (CAS 955584-79-9)
- 7,7-dimethyl-1$l^{4},4-thiazepan-1-one hydrochloride (CAS 1864073-73-3)
- Ethyl 1-(3,5-dimethylphenyl)-1H-1,2,4-triazole-3-carboxylate (CAS 1245643-93-9)
- 1-(4-Fluoro-2-methylphenyl)but-3-en-1-ol (CAS 1378585-51-3)
- 4-Chloro-2-[(4-methylphenyl)methanesulfinyl]-5,6,7,8-tetrahydroquinazoline (CAS 477713-76-1)
- 2'-Deoxyadenosine-5'-diphosphate trisodium salt (CAS 402491-35-4)
- Peptide Impurity 34 (CAS 21282-09-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com