Letermovir Impurity 26 CAS CATO-CP155163
| CAS No. | CATO-CP155163 |
| Molecular Formula | C28H26F4N4O4 |
| Molecular Weight | 558.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Letermovir Impurity 26.
Letermovir Impurity 26 (CAS CATO-CP155163) is a certified pharmaceutical impurity reference standard with the molecular formula C28H26F4N4O4 and a molecular weight of 558.52 g/mol.
The molecular framework of Letermovir Impurity 26 (C28H26F4N4O4) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H26F4N4O4 |
| Molecular Weight | 558.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Letermovir Standards
- Letermovir Impurity 29 (CAS CATO-C4X-291529)
- Letermovir Impurity 45 (CAS CATO-C4X-291545)
- Letermovir Impurity 4 (CAS CATO-CP155165)
- Letermovir Impurity 31 (CAS CATO-C4X-291531)
- Letermovir Impurity 77 (CAS CATO-C4X-291577)
- Letermovir Impurity 33 (CAS CATO-C4X-291533)
- Letermovir impurity 110 (CAS CATO-C4X-2915110)
- Letermovir impurity 125 (CAS CATO-C4X-2915125)
Recommended Standards
- 4',5'-Bis(4-carboxyphenyl)-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid (CAS 1078153-58-8)
- N2,N4,N6-Tris(4-(2H-tetrazol-5-yl)phenyl)-1,3,5-triazine-2,4,6-triamine (CAS 2410710-17-5)
- 4',5'-Bis(3-carboxyphenyl)-[1,1':2',1''-terphenyl]-3,3''-dicarboxylic acid (CAS 1629643-34-0)
- (3S)-tert-butyl 3-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate (CAS 868565-58-6)
- CAS CATO-C3D-262796 (CAS CATO-C3D-262796)
- CAS 2749467-58-9 (CAS 2749467-58-9)
- Clarithromycin EP Impurity H (CAS 127140-69-6)
- 9-(3-aminopropyl)-9H-purin-6-amine dihydrochloride (CAS 23124-11-0)
- 3-chloro-4-(fluorosulfonyl)benzoic acid (CAS 33866-05-6)
- 2-Methoxy-1-methyl-1H-indole (CAS 114113-16-5)
- N-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (CAS 1220036-91-8)
- 1-Bromo-2-difluoromethanesulfonylbenzene (CAS 51679-55-1)
- [2-(1,1-Dimethylethoxy)-2-oxoethyl](2-methylphenyl)[1,2-phenylenebis[diphenylphosphine-κP]]palladium (CAS 351531-17-4)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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