Bexarotene Impurity 3 CAS CATO-C4X-29503
| CAS No. | CATO-C4X-29503 |
| Molecular Formula | C24H28O3 |
| Molecular Weight | 364.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Bexarotene Impurity 3 (CAS CATO-C4X-29503, C24H28O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bexarotene Impurity 3 (C24H28O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 364.48 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H28O3 |
| Molecular Weight | 364.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Bexarotene Standards
- Bexarotene USP Related Compound A (CAS 153559-45-6)
- Bexarotene Impurity 2 (CAS CATO-C4X-29502)
- Bexarotene Fluoro Impurity (CAS 1190848-23-7)
- Bexarotene-d4 (CAS 2182068-00-2)
- Bexarotene-13C4 (CAS 1185030-01-6)
- Bexarotene (CAS 153559-49-0)
- Bexarotene Impurity 1 (CAS 2840408-54-8)
- Bexarotene Impurity 2 (CAS CATO-C4X-29492)
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