Belumosudil Impurity 50 CAS CATO-C4X-298850
| CAS No. | CATO-C4X-298850 |
| Molecular Formula | C20H18ClN3O3 |
| Molecular Weight | 383.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Belumosudil Impurity 50.
CATO supplies Belumosudil Impurity 50 (CAS CATO-C4X-298850), a pharmacopoeial impurity reference standard (molecular formula C20H18ClN3O3, MW 383.83 g/mol) used for the identification and quantification of trace impurities in APIs.
Belumosudil Impurity 50 (C20H18ClN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18ClN3O3 |
| Molecular Weight | 383.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Belumosudil Standards
- Belumosudil Impurity 45 (CAS CATO-C4X-298845)
- Belumosudil Impurity N7 (CAS 911419-33-5)
- Belumosudil Impurity 53 (CAS CATO-C4X-298853)
- Belumosudil Impurity 40 (CAS 2988752-00-5)
- Belumosudil Impurity 37 (CAS CATO-C4X-298837)
- Belumosudil Impurity 35 (CAS CATO-C4X-298835)
- Belumosudil Impurity 43 (CAS 2121561-41-7)
- Belumosudil Impurity 33 (CAS 2121561-37-1)
Recommended Standards
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- Nafamostat Impurity 57 (CAS CATO-C4X-133257)
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- 4-(4-Ethoxyphenyl)pyrimidin-2-amine (CAS 1251055-62-5)
- Gliquidone Impurity 3 (CAS 55974-25-9)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com