Belumosudil Impurity 68 CAS CATO-C4X-298868
| CAS No. | CATO-C4X-298868 |
| Molecular Formula | C6H6Cl2N2O |
| Molecular Weight | 193.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Belumosudil Impurity 68 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Belumosudil Impurity 68 (CAS CATO-C4X-298868, C6H6Cl2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Belumosudil Impurity 68 (C6H6Cl2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H6Cl2N2O |
| Molecular Weight | 193.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Belumosudil Standards
- Belumosudil Impurity 67 (CAS CATO-C4X-298867)
- Belumosudil Impurity 31 (CAS 954269-05-7)
- Belumosudil Impurity 60 (CAS CATO-C4X-298860)
- Belumosudil Impurity 17 (CAS 97454-48-3)
- Belumosudil Impurity 65 (CAS CATO-C4X-298865)
- Belumosudil Impurity 55 (CAS CATO-C4X-298855)
- Belumosudil Impurity 56 (CAS CATO-C4X-298856)
- Belumosudil Impurity 57 (CAS CATO-C4X-298857)
Recommended Standards
- Altretamine Impurity 2 (CAS 2401-64-1)
- 2,4-Dichloro-6-ethylamino-s-triazine (CAS 3440-19-5)
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- 3-(bromomethyl)cyclobutane-1-carboxylic acid (CAS 10555-42-7)
- Ticagrelor EP Impurity D (CAS 274693-26-4)
- Varenicline Impurity 31 (CAS 1333145-89-3)
- Promestriene Impurity 13 (CAS CATO-C4X-220513)
- 3-Methyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)aniline (CAS 1248905-71-6)
- 2-((3-Methylbenzyl)thio)aniline hydrochloride (CAS 1049745-27-8)
- 2-Chloro-N-cyclohexyl-4-iodoaniline (CAS 1157140-88-9)
- 1-Cyclopropyl-4-fluoro-2-iodobenzene (CAS 2412692-07-8)
- Ethyl (S)-3-(4-aminophenyl)-2-(1,3-dioxoisoindolin-2-yl)propanoate (CAS 74743-23-0)
- trans-2-(4-bromo-3-fluorophenyl)cyclopropan-1-amine hydrochloride (CAS 1820581-01-8)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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