Pemigatinib Impurity 4 CAS CATO-C4X-30244
| CAS No. | CATO-C4X-30244 |
| Molecular Formula | C22H25F2N5O3 |
| Molecular Weight | 445.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pemigatinib Impurity 4 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Pemigatinib Impurity 4 (CAS CATO-C4X-30244), a pharmacopoeial impurity reference standard (molecular formula C22H25F2N5O3, MW 445.46 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Pemigatinib Impurity 4 (C22H25F2N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Pemigatinib Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H25F2N5O3 |
| Molecular Weight | 445.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Pemigatinib Standards
Recommended Standards
- Vonoprazan Impurity 174 (CAS CATO-C4X-1020174)
- Fmoc-Asp(OBzl)-OH (CAS 86060-84-6)
- Propargyl-PEG6-NHS ester (CAS 2093153-99-0)
- Fmoc-Asp-OBzl (CAS 86060-83-5)
- Landiolol Impurity 97 (CAS CATO-C4X-262197)
- Metoprolol Impurity 33 (CAS CATO-C4X-136733)
- Netupitant Impurity 60 (CAS CATO-C4X-122360)
- 6-Hydroxy-3-methoxy-2-(trifluoromethyl)pyridine (CAS 1227601-40-2)
- 2-Hydroxy-4-Methoxybenzophenone (CAS 131-57-7)
- cis-4-tert-butylCyclohex-1-yl acetate (CAS 10411-92-4)
- (4-Methoxybenzo[b]thiophen-7-yl)methanamine hydrochloride (CAS 2138546-10-6)
- Methyl 2-Amino-2-(4-pyridyl)acetate Dihydrochloride (CAS 1427475-14-6)
- 2-(3-Methoxypropyl)-4-methylpyrimidine-5-carboxylic acid (CAS 1478683-01-0)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com