N-Nitroso Lorlatinib impurity 1 CAS CATO-C4X-30911
| CAS No. | CATO-C4X-30911 |
| Molecular Formula | C21H20FN7O4 |
| Molecular Weight | 453.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 453.43 g/mol gives N-Nitroso Lorlatinib impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-Nitroso Lorlatinib impurity 1 (CAS CATO-C4X-30911) is a certified pharmaceutical impurity reference standard with the molecular formula C21H20FN7O4 and a molecular weight of 453.43 g/mol.
The molecular framework of N-Nitroso Lorlatinib impurity 1 (C21H20FN7O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-Nitroso Lorlatinib impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20FN7O4 |
| Molecular Weight | 453.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related N Standards
- N-nitroso-deucravacitinib (CAS CATO-C4X-313811)
- N2-Nitroso Deucravacitinib (N2-Nitroso BMS-986165) (CAS CATO-C4X-313817)
- N-Nitroso Cinacalcet Impurity 8 (CAS CATO-C4X-105979)
- N-Nitroso Gatifloxacin Impurity 24 (CAS CATO-C4X-125324)
- N-Nitroso Domperidone (CAS CATO-C4X-142033)
- N-Nitroso Cariprazine (CAS CATO-C4X-24085)
- N-Nitroso Flucloxacillin Impurity 21 (CAS CATO-C4X-164721)
- N-Nitroso Oxacillin Impurity 63 (CAS CATO-C4X-232163)
Recommended Standards
- Toltrazuril Impurity 4 (CAS CATO-C4X-24024)
- (2Z)-2-{4-[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]prop-2-enenitrile (CAS 1164512-73-5)
- N-(4,5-Dihydrothiazol-2-yl)-3-methoxy-4-(2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethoxy)benzamide (CAS 870760-24-0)
- Tetraethyl 2-(4-nitrophenyl)propane-1,1,3,3-tetracarboxylate (CAS 126989-14-8)
- Cefmetazole Impurity 67 (CAS CATO-C4X-150767)
- Terbinafine Impurity 10 (CAS 126764-17-8)
- Brexpiprazole Impurity 48 (CAS 2059942-13-9)
- N-(4-(N-(1-Methylpyrrolidin-2-ylidene)sulfamoyl)phenyl)acetamide (CAS 124869-79-0)
- 3-(2,5-dichlorophenoxy)propanoic acid (CAS 7170-68-5)
- (4-Methyl-benzyl)-(2-pentafluoroethyloxyethyl)-amine (CAS 1208078-62-9)
- Petroselinic Acid-Methyl Ester (CAS 2777-58-4)
- 6-Bromo-2-{2-[3-(trifluoromethyl)phenyl]ethenyl}quinoline-4-carboxylic acid (CAS 926269-29-6)
- 5-OH-imidacloprid-13C-15N2 (CAS CATO-CCPD102480)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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