Darolutamide Impurity 28 CAS CATO-C4X-310628
| CAS No. | CATO-C4X-310628 |
| Molecular Formula | C19H23ClN6O2 |
| Molecular Weight | 402.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Darolutamide Impurity 28 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Darolutamide Impurity 28 (CAS CATO-C4X-310628, C19H23ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Darolutamide Impurity 28 (C19H23ClN6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Darolutamide Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H23ClN6O2 |
| Molecular Weight | 402.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Darolutamide Standards
- Darolutamide D4 (CAS 2484757-19-7)
- Darolutamide Impurity 34 (CAS CATO-C4X-310634)
- Darolutamide (CAS 1297538-32-9)
- Darolutamide impurity 10 (CAS 1976022-48-6)
- Darolutamide impurity 11 (CAS 1976022-49-7)
- Darolutamide Impurity 13 (Mixture of Diastereomers) (CAS 2407645-49-0)
- Darolutamide Impurity 14 (CAS CATO-C4X-310614)
- Darolutamide Impurity 15 (CAS CATO-C4X-310615)
Recommended Standards
- N-(5-chloro-2-methylphenyl)-2-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)acetamide (CAS 332909-59-8)
- A-867744, >98% (HPLC) (CAS 1000279-69-5)
- 1-(4-(3-(4-Chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3,3-dimethylazetidin-2-one (CAS 303985-95-7)
- 2,4,7-Tribromobenzo[b]thiophene 1,1-dioxide (CAS 887573-04-8)
- Olmesartan Impurity 69 (CAS 129482-56-0)
- Mometasone Furoate EP Impurity N (CAS 352315-75-4)
- Pemafibrate Impurity 85 (CAS CATO-C4X-290385)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(1H-imidazol-1-yl)furan-2-yl)boronate (CAS 2223054-59-7)
- 3C-B-FLY (CAS 178557-19-2)
- 3-Chloro-N-(2-(2,4-dimethyl-7-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-1-yl)ethyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 478262-18-9)
- 2-Phenyl-1-(pyridin-2-yl)ethan-1-amine (CAS 16273-81-7)
- 5-Methyl-N-(thiophen-2-ylmethyl)pyrazine-2-carboxamide (CAS 1037938-06-9)
- 1-(4-Chlorophenyl)-1h-1,2,3,4-tetrazole (CAS 25108-32-1)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com