Darolutamide impurity 10 CAS 1976022-48-6
| CAS No. | 1976022-48-6 |
| Molecular Formula | C19H19ClN6O2 |
| Molecular Weight | 398.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Darolutamide impurity 10 (C19H19ClN6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Darolutamide impurity 10 (CAS 1976022-48-6) is a certified pharmaceutical impurity reference standard with the molecular formula C19H19ClN6O2 and a molecular weight of 398.85 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Darolutamide impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19ClN6O2 |
| Molecular Weight | 398.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Darolutamide Standards
- Darolutamide (CAS 1297538-32-9)
- Darolutamide impurity 11 (CAS 1976022-49-7)
- Darolutamide Impurity 13 (Mixture of Diastereomers) (CAS 2407645-49-0)
- Darolutamide Impurity 14 (CAS CATO-C4X-310614)
- Darolutamide Impurity 15 (CAS CATO-C4X-310615)
- Darolutamide Impurity 31 (CAS CATO-C4X-310631)
- Darolutamide Impurity 27 (CAS 1297538-27-2)
- Darolutamide Impurity 30 (CAS CATO-C4X-310630)
Recommended Standards
- Lornoxicam Impurity 10 (CAS CATO-C4X-201610)
- Rebamipide impurity 28 (CAS CATO-C4X-152328)
- 2-{[[(anilinocarbonyl)oxy](methyl)amino]methylene}-5-(4-chlorophenyl)-1,3-cyclohexanedione 338399-51-2 KS-000033VT (CAS 338399-51-2)
- N-(1-((3-chloro-4-methoxyphenyl)amino)-2-oxo-2-(p-tolyl)ethyl)furan-2-carboxamide (CAS 335421-10-8)
- Amlodipine Impurity 105 Oxalate (CAS CATO-C4X-1095105)
- Sibutramine Impurity 6 (CAS 2758418-79-8)
- Vazegepant Impurity 14 (CAS 928014-62-4)
- Phentolamine Mesilate EP Impurity C (CAS 61537-49-3)
- 2-3-5-Tri-O-benzoyluridine (CAS 1748-04-5)
- 1,4-dioxepan-6-ylmethanamine (CAS 1393174-99-6)
- 2-Bromo-4,5-difluoronitrobenzene (CAS 321-17-5)
- Methyl 3-iodo-4-isopropylbenzoate (CAS 100127-58-0)
- 4-Isobutyl-5-(3-(morpholinosulfonyl)phenyl)-4h-1,2,4-triazole-3-thiol (CAS 748776-49-0)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
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