Lofexidine Impurity 1 CAS CATO-C4X-31901
| CAS No. | CATO-C4X-31901 |
| Molecular Formula | C11H10Cl2N2O |
| Molecular Weight | 257.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lofexidine Impurity 1 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Lofexidine Impurity 1 (CAS CATO-C4X-31901) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10Cl2N2O and a molecular weight of 257.12 g/mol.
Based on its molecular formula C11H10Cl2N2O, Lofexidine Impurity 1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 257.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lofexidine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10Cl2N2O |
| Molecular Weight | 257.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lofexidine Standards
- (R)-Lofexidine (CAS 81447-78-1)
- (S)-Lofexidine (CAS 81447-79-2)
- Lofexidine - API Standards (CAS 31036-80-3)
- Lofexidine Ethyl Ester Impurity (CAS 344559-34-8)
- Lofexidine-d4 Hydrochloride (CAS 78302-26-8)
- Lofexidine Amide Impurity (CAS 344411-67-2)
- Lofexidine Nitrile Impurity (CAS 78302-27-9)
- Lofexidine D4 HCl (CAS 1206845-57-9)
Recommended Standards
- Loxoprofen Impurity 18 (CAS 99807-54-2)
- n-(3-Aminopropyl)-3-bromobenzamide (CAS 1016507-95-1)
- Loxoprofen Impurity 152 (CAS CATO-C4X-1488152)
- N-(3-aminopropyl)-4-bromobenzamide (CAS 1016790-51-4)
- Minodronic Impurity 4 (CAS 17745-04-9)
- Mirabegron impurity 95 (CAS CATO-C4X-103295)
- Pinaverium Impurity 12 Chloride (CAS CATO-C4X-246712)
- 2-(3-Chlorophenyl)-5-methylbenzo[d]thiazole (CAS 1242303-21-4)
- Rel-(1R,5R)-6,8-dioxabicyclo[3.2.1]oct-3-en-2-one (CAS 33647-85-7)
- Propane-1,2,3-triyl tris(3-oxooctanoate) (CAS 68444-14-4)
- 76243-25-9 4-(Benzyloxy)-3-fluoroaniline--hydrogen chloride (1/1) DTXSID20633117 (CAS 76243-25-9)
- 3-(1,4-diazepan-1-ylsulfonyl)benzoic acid (CAS 1267215-92-8)
- Cefazedone (CAS 56187-47-4)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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