Loxoprofen Impurity 18 CAS 99807-54-2
| CAS No. | 99807-54-2 |
| Molecular Formula | C11H13BrO2 |
| Molecular Weight | 257.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Loxoprofen Impurity 18.
Loxoprofen Impurity 18 (CAS 99807-54-2) is a certified pharmaceutical impurity reference standard with the molecular formula C11H13BrO2 and a molecular weight of 257.12 g/mol.
The molecular framework of Loxoprofen Impurity 18 (C11H13BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loxoprofen Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13BrO2 |
| Molecular Weight | 257.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
Related Loxoprofen Standards
- Loxoprofen Impurity 104 (CAS 56607-18-2)
- Loxoprofen Impurity 151 (CAS 1218987-96-2)
- Loxoprofen Impurity 152 (CAS CATO-C4X-1488152)
- Loxoprofen Impurity 114 (CAS CATO-C4X-1488114)
- Loxoprofen Impurity 11 (CAS 81762-92-7)
- Loxoprofen impurity 74 (CAS CATO-C4X-148874)
- Loxoprofen Impurity 146 (CAS CATO-C4X-1488146)
- Loxoprofen Impurity 15(Mixture of Diastereomers) (CAS 1091621-62-3)
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