Enarodustat Impurity 22 CAS CATO-C4X-322822
| CAS No. | CATO-C4X-322822 |
| Molecular Formula | C14H9Cl4N5O4 |
| Molecular Weight | 453.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Enarodustat Impurity 22 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Enarodustat Impurity 22 (CAS CATO-C4X-322822) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9Cl4N5O4 and a molecular weight of 453.06 g/mol.
Based on its molecular formula C14H9Cl4N5O4, Enarodustat Impurity 22 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 453.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl4N5O4 |
| Molecular Weight | 453.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 0.95 |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Enarodustat Standards
- Enarodustat Impurity 32 (CAS CATO-C4X-322832)
- Enarodustat Impurity 33 (CAS CATO-C4X-322833)
- Enarodustat Impurity 11 (CAS CATO-C4X-322811)
- Enarodustat Impurity 13 (CAS CATO-C4X-322813)
- Enarodustat Impurity 2 (CAS CATO-C4X-32282)
- Enarodustat Impurity 23 (CAS CATO-C4X-322823)
- Enarodustat Impurity 5 (CAS CATO-C4X-32285)
- Enarodustat Impurity 20 (CAS CATO-C4X-322820)
Recommended Standards
- tert-Butyl 2,5-diiodopyridin-3-yl carbonate (CAS 1138444-30-0)
- 2-Bromo-5-(tributylstannyl)thiazole (CAS 1062589-73-4)
- tert-Butyl Cetirizine-d8 (CAS 1189466-71-4)
- 2-bromo-5-(tributylstannyl)thiazole, 95% (CAS 1447761-46-7)
- Phentolamine Impurity 19 (CAS CATO-C4X-224719)
- Talazoparib Impurity 6 (CAS CATO-C4X-33736)
- Cefixime Impurity 108 (CAS CATO-C4X-1139108)
- 1-n-(3-Methoxypropyl)benzene-1,3-diamine (CAS 1152561-69-7)
- 4-Chloro-N-(4,6-diphenylpyrimidin-2-yl)benzamide (CAS 820961-59-9)
- 2,7-dichloro-3,4-dihydroquinazolin-4-one (CAS 20197-96-0)
- 4-Tetrahydropyranyl Methanesulfonate (CAS 134419-59-3)
- 4-((3,4-Dichlorobenzyl)amino)butan-2-ol (CAS 1343592-49-3)
- tert-Butyl 7-fluoro-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 912846-67-4)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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